2-(pyridine-2-yl)-1H-imidazolo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine | 1352399-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(pyridine-2-yl)-1H-imidazolo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine
• 英文别名: 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine；20-pyridin-2-yl-15,19,21,25-tetrazahexacyclo[12.11.0.02,7.08,13.016,24.018,22]pentacosa-1(25),2,4,6,8,10,12,14,16(24),17,19,22-dodecaene
• CAS: 1352399-50-8
• 化学式: C₂₆H₁₅N₅
• 分子量: 397.439
• InChiKey: OIONTTLINMJSAX-UHFFFAOYSA-N

物化性质

• 沸点：
  768.0±53.0 °C(predicted)
• 密度：
  1.437±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.03
• 重原子数：
  31.0
• 可旋转键数：
  1.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.35
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  顺-双(2,2-二吡啶)二氯化钌(II) 水合物 、 2-(pyridine-2-yl)-1H-imidazolo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine 、 sodium perchlorate 以 乙二醇 为溶剂， 以68.9%的产率得到[Ru(2-(pyridine-2-yl)-1H-imidazolo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine)(2,2'-bipyridine)2](ClO4)2*H2O
  参考文献：
  名称：

  DNA-binding and photocleavage studies of ruthenium(II) complexes containing asymmetric intercalative ligand

  摘要：

  A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine (pidbp) and its ruthenium complexes [Ru(L)(2)(pidbp)](2+). (L=bpy (2, 2'- bipyridine), phen (1, 10 - phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, H-1 NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex [Ru(bPY)(2)(Pidbp)](2+) 4 exhibits its DNA "molecular light switch" properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.11.014
• 作为产物：
  描述：

  N,N'-(4,5-二硝基-1,2-亚苯基)双(4-甲基苯磺酰胺) 在 硫酸 、 水 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 10.0h， 生成 2-(pyridine-2-yl)-1H-imidazolo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine
  参考文献：
  名称：

  DNA-binding and photocleavage studies of ruthenium(II) complexes containing asymmetric intercalative ligand

  摘要：

  A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine (pidbp) and its ruthenium complexes [Ru(L)(2)(pidbp)](2+). (L=bpy (2, 2'- bipyridine), phen (1, 10 - phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, H-1 NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex [Ru(bPY)(2)(Pidbp)](2+) 4 exhibits its DNA "molecular light switch" properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.11.014

文献信息

• DNA-binding and photocleavage studies of ruthenium(II) complexes containing asymmetric intercalative ligand
  作者：Xue-Wen Liu、Yuan-Dao Chen、Lin Li、Ji-Lin Lu、Da-Shun Zhang

  DOI：10.1016/j.saa.2011.11.014

  日期：2012.2

  A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine (pidbp) and its ruthenium complexes [Ru(L)(2)(pidbp)](2+). (L=bpy (2, 2'- bipyridine), phen (1, 10 - phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, H-1 NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex [Ru(bPY)(2)(Pidbp)](2+) 4 exhibits its DNA "molecular light switch" properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen. (C) 2011 Elsevier B.V. All rights reserved.