4-dimethylaminophenethyl mesylate | 281678-05-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-dimethylaminophenethyl mesylate
• 英文别名: 2-[4-(dimethylamino)phenyl]ethyl methanesulfonate
• CAS: 281678-05-5
• 化学式: C₁₁H₁₇NO₃S
• 分子量: 243.327
• InChiKey: FPTOYKZQLHMRBS-UHFFFAOYSA-N

物化性质

• 沸点：
  416.8±28.0 °C(Predicted)
• 密度：
  1.191±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-dimethylaminophenethyl mesylate 、 (R)-2-哌啶甲醇 在 sodium iodide 、 sodium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 、 乙腈 为溶剂， 生成 (R)-2-Hydroxymethyl-1-(4-dimethylaminophenethyl)piperidine
  参考文献：
  名称：

  Oxazepine derivatives and medicine containing the same

  摘要：

  本发明提供(R)-5,11-二氢-5-[1-(4-甲氧基苯乙基)哌啶-2-基甲基]二苯并[b,e][1,4]噁唑啉，(R)-5,11-二氢-5-[1-(4-二甲氨基苯乙基)哌啶-2-基甲基]二苯并[b,e][1,4]噁唑，以及类似它们的化合物和含有这种化合物的药物组合物。这些化合物可用于治疗或预防胃肠道异常运动功能，特别是肠易激综合征。

  公开号：

  US20020099047A1
• 作为产物：
  描述：

  4-(二甲基氨基)苯乙醇 、 甲基磺酰氯 以 二氯甲烷 为溶剂， 生成 4-dimethylaminophenethyl mesylate
  参考文献：
  名称：

  In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series

  摘要：

  Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.067

文献信息

• Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same
  申请人：Ajinomoto Co., Inc.

  公开号：US20040110742A1

  公开（公告）日：2004-06-10

  The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts. 1

  本发明提供了以下公式（1）所表示的二氢二苯并噁唑啉衍生物，其类似物以及含有它们的制药组合物。这些化合物具有改善胃肠道功能性疾病的优异效果。
• Pheny (alkyl)carboxylic acid derivatives and dionic phenylalkylheterocyclic derivatives and their use as medicines with serum glucose and/or serum lipid lowering activity
  申请人：Giannessi Fabio

  公开号：US20050032787A1

  公开（公告）日：2005-02-10

  Formula (I) compounds are described: Where the groups are as defined here below, and their use as medinies, particularly as serum glucose and serum lipid lowering agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2, and its complications, Syndrome X, the various forms of insulin resistance, and hyperlipidaemias, and present reduced side effects, and, particularly, reduced or no liver toxicity.

  描述了公式(I)化合物：其中各组如下所定义，并且它们的用途作为药物，特别是作为血清葡萄糖和血清脂质降低剂。所述药物对于预防和治疗糖尿病，特别是2型糖尿病及其并发症，综合征X，各种形式的胰岛素抵抗和高脂血症非常有用，并且具有减少的副作用，特别是减少或无肝毒性。
• NOVEL INDOLES ARE CANNABINOID RECEPTOR LIGANDS
  申请人：Frost Jennifer M.

  公开号：US20110065685A1

  公开（公告）日：2011-03-17

  The present invention provides novel compounds of Formula (I) which are CB 2 selective ligands useful for the treatment of pain.

  本发明提供了式（I）的新化合物，它们是CB2选择性配体，可用于治疗疼痛。
• OXAZEPINE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：Ajinomoto Co., Inc.

  公开号：EP1142884A1

  公开（公告）日：2001-10-10

  The present invention provides (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b,e] [1,4]oxazepine, (R)-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepine, compounds analogous to them and pharmaceutical compositions containing such a compound. These compounds are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, particularly irritable bowel syndrome.

  本发明提供了(R)-5,11-二氢-5-[1-(4-甲氧基苯乙基)哌啶-2-基甲基]二苯并[b,e][1,4]氧氮杂卓、(R)-5,11-二氢-5-[1-(4-二甲基氨基苯乙基)哌啶-2-基甲基]二苯并[b,e][1,4]氧氮杂卓、与它们类似的化合物以及含有这种化合物的药物组合物。这些化合物可用于治疗或预防胃肠道运动功能异常，尤其是肠易激综合征。
• DIHYDRODIARYLOXAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1403258A1

  公开（公告）日：2004-03-31

  The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts.

  本发明提供了由下式[1]代表的二氢二氮杂卓衍生物、其类似物以及含有它们的药物组合物。这些化合物在改善胃肠道功能性疾病方面具有极佳的效果。