6-Methyl-[1,3]dioxolo[4,5-g]quinoxaline | 66353-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-Methyl-[1,3]dioxolo[4,5-g]quinoxaline
• CAS: 66353-97-7
• 化学式: C₁₀H₈N₂O₂
• 分子量: 188.18
• InChiKey: MDKOMFXWBKGKQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙酮醛 、 1,2-二氨基-4,5-亚甲基二氧基苯双盐酸盐 生成 6-Methyl-[1,3]dioxolo[4,5-g]quinoxaline
  参考文献：
  名称：

  YAMAGUCHI, MASATOSHI;HARA, SHUUJI;NAKAMURA, MASARU, ANAL. CHIM. ACTA, 221,(1989) N, C. 163-166

  摘要：

  DOI：

文献信息

• Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1595871A2

  公开（公告）日：2005-11-16

  The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

  本发明提供了在代谢型谷氨酸受体上具有活性的化合物和含有这些化合物的药物组合物。这些化合物可用于治疗神经系统疾病和失调。本发明还公开了制备这些化合物的方法。
• YAMAGUCHI, MASATOSHI;HARA, SHUUJI;NAKAMURA, MASARU, ANAL. CHIM. ACTA, 221,(1989) N, C. 163-166
  作者：YAMAGUCHI, MASATOSHI、HARA, SHUUJI、NAKAMURA, MASARU

  DOI：——

  日期：——
• METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1196397B1

  公开（公告）日：2005-08-17
• [EN] METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES<br/>[FR] ANTAGONISTES DU RECEPTEUR DE GLUTAMATE METABOTROPIQUE ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES DU SYSTEME NERVEUX CENTRAL
  申请人：NPS PHARMA INC

  公开号：WO2000073283A1

  公开（公告）日：2000-12-07

  The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.