6,7-dimethylthianaphthalene | 37610-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 6,7-dimethylthianaphthalene
• 英文别名: 6,7-Dimethyl-thionaphthen；6,7-dimethyl-benzo[b]thiophene；Benzothiophene, 6,7-dimethyl；6,7-dimethyl-1-benzothiophene
• CAS: 37610-98-3
• 化学式: C₁₀H₁₀S
• 分子量: 162.255
• InChiKey: ADDQFYLSEMVGPW-UHFFFAOYSA-N

物化性质

• 沸点：
  268.4±9.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)
• 保留指数：
  1436.9

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  噻吩并[2,3-c]呋喃-4,6-二酮 、 3,4-二甲基噻吩 生成 6,7-dimethylthianaphthalene
  参考文献：
  名称：

  REINECKE, M. G.;NEWSOM, J. G.;ALMQVIST, K. A., TETRAHEDRON, 1981, 37, N 24, 4151-4157

  摘要：

  DOI：

文献信息

• Cycloaddition reactions of 2,3-didehydrothiophene generated by flow vacuum thermolysis of thiophene-2,3-dicarboxylic anhydride
  作者：Manfred G. Reinecke、James G. Newsom、K.Anders Almqvist

  DOI：10.1016/0040-4020(81)85005-3

  日期：1981.1

  Flow vacuum thermolysis (FVT) of thiophene-2,3-dicarboxylic anhydride (2) in the presence of 2,3-dimethylbutadiene (6) gives, in addition to 5,6-dimethylthianaphthene (9). small quantities of a dihydrodimethylthianaphthene (12) and another dimethylthianaphthene (13) which is probably also formed by dehydrogenation of 12 with chloranil. The partial structures of these minor products are consistent with

  在2，3-二甲基丁二烯（6）的存在下，噻吩-2，3-二羧酸酐（2）的流式真空热解（FVT）除5,6-二甲基噻吩（9）外还产生。少量的二氢二甲基噻吩（12）和另一种二甲基噻吩（13），也可能是通过用氯乙腈将12脱氢而形成的。这些次要产物的部分结构与它们的形成是一致的，它们是由6与中间体亚芳基2,3-二氢噻吩（1）之间的[2 + 2]-环加成反应，然后重排生成的加合物11和进行脱氢而形成的。在2,5-（17b）或3,4-二甲基噻吩（17c）存在下的FVT为2时，也得到了二甲基噻吩的混合物（1822，23），这可以合理地认为是由芳烃1与噻吩17的[4 + 2]-和两个[2 + 2]-环加成引起的，随后进行了脱硫。证明了产物18、22和23缺乏平衡，并且讨论了它们的来源作为芳烃1的结构和反应性的函数。
• SULTAM DERIVATIVES
  申请人：MAEKAWARA Naomi

  公开号：US20090192154A1

  公开（公告）日：2009-07-30

  A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.

  提供一种以下式（1）描述的磺酰胺衍生物，具有对聚集素酶活性的抑制作用。该式（1）的磺酰胺衍生物及其盐在哺乳动物包括人类的活体内表现出对聚集素酶活性的强抑制作用，并且可用作制药剂的活性成分，用于预防和/或治疗由聚集素降解引起的各种疾病。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• LIQUID CRYSTAL COMPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20170335191A1

  公开（公告）日：2017-11-23

  A liquid crystal composition which prevents production of an alignment defect of a liquid crystal compound and also has excellent storage stability during dissolution in a solvent is provided. The liquid crystal composition is suitable for constituting a retardation film capable of favorable circular polarization conversion. The liquid crystal composition includes a polymerizable liquid crystal compound having 3 or more ring structures in the main chain, and aluminum. A content of the aluminum is 1 ppm or more and 170 ppm or less relative to the polymerizable liquid crystal compound.

  提供了一种液晶组合物，可以防止液晶化合物的对准缺陷产生，并且在溶剂中溶解时具有优异的储存稳定性。该液晶组合物适用于构成具有良好圆偏振转换的减速膜。该液晶组合物包括具有3个或更多环结构的可聚合液晶化合物和铝。铝的含量相对于可聚合液晶化合物为1 ppm或更多，170 ppm或更少。
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。