acenaphthenone o-nitrophenylhydrazone | 107522-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: acenaphthenone o-nitrophenylhydrazone
• 英文别名: acenaphthen-1-one-(2-nitro-phenylhydrazone)；Acenaphthen-1-on-(2-nitro-phenylhydrazon)；N-[(Z)-2H-acenaphthylen-1-ylideneamino]-2-nitroaniline
• CAS: 107522-74-7
• 化学式: C₁₈H₁₃N₃O₂
• 分子量: 303.32
• InChiKey: DEJCFKIDZDIERP-SILNSSARSA-N

物化性质

• 沸点：
  512.8±60.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-硝基苯肼 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 13.0h， 生成 acenaphthenone o-nitrophenylhydrazone
  参考文献：
  名称：

  Tsuge, Otohiko; Hatta, Taizo; Kojima, Hisashi, Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1283 - 1288

  摘要：

  DOI：

文献信息

• Construction and analysis of hemin binding protein mutants in the oral pathogen Treponema denticola
  作者：Xiaoping Xu、David Kolodrubetz

  DOI：10.1016/s0923-2508(02)01370-0

  日期：2002.11

  Treponema denticola, a periodontal pathogen, can use hemin as its sole iron source. The organism synthesizes two low-iron-induced outer-membrane hemin-binding proteins, HbpA and HbpB. To characterize genetically the function of these two novel proteins, standard recombinant DNA procedures and electroporation were used to construct T denticola strains in which the genomic copies of either hbpA or both hbpA and hbpB were interrupted with an erythromycin resistance cassette. Northern blot and RT-PCR analyses verified that the normal hbpA transcripts were missing in both mutants. The hbpA mutation also had a polar effect on the transcription of hbpB and thus neither mutant strain transcribes the downstream hbpB gene. The parental and hbp mutant strains had similar growth properties in normal media, but the mutants reached a lower cell density than parental cells in iron-restricted media. The results indicate that HbpA and/or HbpB are required for efficient iron utilization but that there is an additional system that can help T denticola acquire iron. The growth defect of the mutants was totally restored by lactoferrin but only partially restored by adding exogenous hemin or inorganic iron. Thus, hbpA and/or hhpB specifically facilitate hemin and iron utilization under low iron conditions and are presumably important for T denticola virulence in the host environment. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• Tsuge, Otohiko; Hatta, Taizo; Kojima, Hisashi, Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1283 - 1288
  作者：Tsuge, Otohiko、Hatta, Taizo、Kojima, Hisashi、Miyahara, Nobutaka、Sugaya, Masafumi

  DOI：——

  日期：——