Zinc dipicrate | 16824-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Zinc dipicrate
• 英文别名: zinc;2,4,6-trinitrophenolate
• CAS: 16824-81-0
• 化学式: C12H4N6O14Zn
• 分子量: 521.6
• InChiKey: CJDKMIIOFVCHNV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  33
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  321
• 氢给体数：
  0
• 氢受体数：
  14

制备方法与用途

类别：爆炸物品

爆炸物危险特性

• 热、摩擦和撞击均可能引发爆炸

可燃性危险特性

• 具有可燃性，在火场会排出含铅和氮氧化物的辛辣刺激烟雾

储运特性

• 库房需保持低温、通风和干燥
• 需注意防火，并避免震动和摩擦

灭火剂

• 可使用水、二氧化碳、干粉或泡沫进行灭火

反应信息

• 作为反应物：
  描述：

  替马西泮 、 Zinc dipicrate 生成 dizinc;7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one;2,4,6-trinitrophenolate
  参考文献：
  名称：

  GAJEWSKA, MARIA;GOLDNIK, ANNA;WOJCIK, ELZBIETA;LUKASIAK, EWA, CHEM. ANAL., 33,(1988) N 1, C. 155-162

  摘要：

  DOI：

文献信息

• METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0589047A1

  公开（公告）日：1994-03-30

  A method of treating infectious diseases caused by bacteria or fungi by administering a zinc compound and at least one compound selected from the group consisting of hinokitiol and salts thereof; a method of preventing putrefaction of cosmetics by adding thereto a zinc compound and at least one compound selected from the group consisting of hinokitiol and salts thereof; and antibacterial/antifungal agents and cosmetics each containing a zinc compound and at least one compound selected from the goup consisting of hinokitiol and salts thereof.

  一种通过施用锌化合物和至少一种选自桧皮酚及其盐类的化合物来治疗由细菌或真菌引起的传染性疾病的方法；一种通过在化妆品中添加锌化合物和至少一种选自桧皮酚及其盐类的化合物来防止化妆品腐败的方法；以及含有锌化合物和至少一种选自桧皮酚及其盐类的化合物的抗菌/抗真菌剂和化妆品。
• Chemical compositions and methods of making them
  申请人：JR Chemicals

  公开号：EP1816116A1

  公开（公告）日：2007-08-08

  Reaction products of polyfunctional compounds with two or more coordination elements are described.

  描述了具有两个或更多配位元素的多官能团化合物的反应产物。
• Compositions, kits and regimens for the treatment of skin, especially décolletage
  申请人：Jr Chem, LLC

  公开号：EP2087880A2

  公开（公告）日：2009-08-12

  Compositions, kits and regimens for treatment of damaged skin, especially décolletage, include application of a retinoid, hydroquinone or hydroquinone derivatives, and a composition containing a multi-metal complex.

  治疗受损皮肤（尤其是肩部）的组合物、套装和方案包括使用维甲酸、对苯二酚或对苯二酚衍生物，以及含有多金属复合物的组合物。
• Fast acting inhibitor of gastric acid secretion
  申请人：YALE UNIVERSITY

  公开号：US10278989B2

  公开（公告）日：2019-05-07

  The present invention relates to the use of pharmaceutically acceptable zinc salts, in particular, zinc chloride and zinc acetate, alone or optionally, in combinations with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, including acid secretion in the fundus (by inhibiting vacuolar H+-ATPase or H+/K+-ATPase) and upper body region of the stomach (by inhibiting H+/K+-ATPase), thus raising the pH of gastric juices in rapid fashion and decreasing the duration of stomach acid release during a secretagogue phase. This method is also directed to treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non-responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion.

  本发明涉及药学上可接受的锌盐，特别是氯化锌和醋酸锌，单独或与一种或多种蛋白泵抑制剂（PPI）、H2 受体阻滞剂、抗幽门螺杆菌抗生素/抗菌剂、细胞保护剂或本文所述的复方制剂组合使用，以提供快速作用和可选的长效作用，减少胃酸分泌，包括胃酸在胃中的分泌。特别是氯化锌和醋酸锌，单独使用或与一种或多种蛋白泵抑制剂（PPI）、H2 受体阻滞剂、抗幽门螺杆菌抗生素/抗菌剂、细胞保护剂或本文另外描述的复方制剂联合使用，可在减少胃酸分泌，包括胃底（通过抑制空泡 H+-ATP 酶或 H+/K+-ATP 酶）和胃上部（通过抑制 H+/K+-ATP 酶）的胃酸分泌方面提供快速作用和可选的长效作用，从而快速提高胃液的 pH 值，减少分泌期胃酸释放的持续时间。本方法还可用于治疗胃食管反流病（GERD）、非胃食管反流病（NERD）、卓-艾综合征（ZE 病）、溃疡病和胃癌等疾病，以及预防或降低溃疡病的可能性。此外，本方法还可用于治疗对质子泵抑制剂（PPI）无反应的患者，并可替代传统疗法或因快速、完全抑制分泌物诱导的酸分泌而导致的病症。
• GAJEWSKA, MARIA;GOLDNIK, ANNA;WOJCIK, ELZBIETA;LUKASIAK, EWA, CHEM. ANAL., 33,(1988) N 1, C. 155-162
  作者：GAJEWSKA, MARIA、GOLDNIK, ANNA、WOJCIK, ELZBIETA、LUKASIAK, EWA

  DOI：——

  日期：——