(2-hydroxy-benzylideneamino)acetonitrile | 122373-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2-hydroxy-benzylideneamino)acetonitrile
• 英文别名: (2-Hydroxy-benzylideneamino)-acetonitrile；2-[(2-hydroxyphenyl)methylideneamino]acetonitrile
• CAS: 122373-28-8
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: XSOYYIJICFAGDV-UHFFFAOYSA-N

物化性质

• 熔点：
  51-53 °C
• 沸点：
  312.0±27.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-hydroxy-benzylideneamino)acetonitrile 、 水杨醛 在 三乙胺 作用下， 以 乙醇 为溶剂， 以68%的产率得到2-(3,9-dihydrochromeno[3,2-d]imidazol-2-yl)phenol
  参考文献：
  名称：

  2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles: a facile synthesis from salicylaldehydes and arylideneaminoacetonitrile

  摘要：

  2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles were prepared by a one-pot cascade reaction involving salicylaldehydes and arylideneaminoacetonitriles. These novel compounds were isolated in 11-95% yield after reflux in ethanol and triethylamine. A dimeric structure was also identified and partially evolved to the tricyclic product in DMSO solution, according to an evolution study by H-1 NMR spectroscopy. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.035
• 作为产物：
  描述：

  氨基乙腈盐酸盐 、 水杨醛 在 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以97%的产率得到(2-hydroxy-benzylideneamino)acetonitrile
  参考文献：
  名称：

  2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles: a facile synthesis from salicylaldehydes and arylideneaminoacetonitrile

  摘要：

  2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles were prepared by a one-pot cascade reaction involving salicylaldehydes and arylideneaminoacetonitriles. These novel compounds were isolated in 11-95% yield after reflux in ethanol and triethylamine. A dimeric structure was also identified and partially evolved to the tricyclic product in DMSO solution, according to an evolution study by H-1 NMR spectroscopy. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.035

文献信息

• 2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles: a facile synthesis from salicylaldehydes and arylideneaminoacetonitrile
  作者：Marta Costa、Fernanda Proença

  DOI：10.1016/j.tet.2011.01.035

  日期：2011.3

  2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles were prepared by a one-pot cascade reaction involving salicylaldehydes and arylideneaminoacetonitriles. These novel compounds were isolated in 11-95% yield after reflux in ethanol and triethylamine. A dimeric structure was also identified and partially evolved to the tricyclic product in DMSO solution, according to an evolution study by H-1 NMR spectroscopy. (C) 2011 Elsevier Ltd. All rights reserved.