1-methoxymethyl-2-naphthol | 4855-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-methoxymethyl-2-naphthol
• 英文别名: 1-Methoxymethyl-[2]naphthol；1-Methoxymethyl-<2>naphthol；1-(Methoxymethyl)-2-naphthol；1-(methoxymethyl)naphthalen-2-ol
• CAS: 4855-10-1
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: NAIGODNRSKGHCR-UHFFFAOYSA-N

物化性质

• 熔点：
  195-196 °C
• 沸点：
  324.1±17.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methoxymethyl-2-naphthol 生成 2-acetoxy-1-methoxymethyl-naphthalene
  参考文献：
  名称：

  Reaction of Phenolic Mannich Base Methiodides and Oxides with Various Nucleophiles

  摘要：

  DOI：

  10.1021/ja01522a052
• 作为产物：
  描述：

  (2-hydroxy-[1]naphthylmethyl)-trimethyl-ammonium; iodide 在 甲醇 、 sodium methylate 作用下， 生成 1-methoxymethyl-2-naphthol
  参考文献：
  名称：

  Reaction of Phenolic Mannich Base Methiodides and Oxides with Various Nucleophiles

  摘要：

  DOI：

  10.1021/ja01522a052

文献信息

• Convenient Method for the ortho-Formylation of Phenols.
  作者：Nini U. Hofsløkken、Lars Skattebøl、Fredrik Johansson、Sophie K. Bertilsson、Pher G. Andersson、Jørgen Møller、Alexander Senning、Xin-Kan Yao、Hong-Gen Wang、J. -P. Tuchagues、Mattias Ögren

  DOI：10.3891/acta.chem.scand.53-0258

  日期：——

  Phenolic derivatives are formylated selectively ortho to the hydroxy group by paraformaldehyde with magnesium dichloride triethylamine as base. With alkyl-substituted phenols excellent yields of the corresponding salicylaldehyde derivatives were obtained. Similar results were obtained with chloro-substituted phenols and with 3-and 4-methoxyphenol while 2-methoxyphenol was unreactive. A good yield of methyl 3-formyl-4-hydroxybenzoate was obtained by this method as well, but generally phenols with electron-attracting groups reacted sluggishly; the long reaction times required caused the formation of by-products. particularly MOM-derivatives of the phenols.
• Reaction of Phenolic Mannich Base Methiodides and Oxides with Various Nucleophiles
  作者：Pete D. Gardner、Hossein Sarrafizadeh Rafsanjani、Leon Rand

  DOI：10.1021/ja01522a052

  日期：1959.7