N,N-bis-(2-aminoethyl)-t-butylamine | 24802-26-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-bis-(2-aminoethyl)-t-butylamine
• 英文别名: N~1~-(2-Aminoethyl)-N~1~-tert-butylethane-1,2-diamine；N'-(2-aminoethyl)-N'-tert-butylethane-1,2-diamine
• CAS: 24802-26-4
• 化学式: C₈H₂₁N₃
• 分子量: 159.275
• InChiKey: CLTZYSIIEUDPLB-UHFFFAOYSA-N

物化性质

• 沸点：
  208.3±8.0 °C(Predicted)
• 密度：
  0.908±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,5-噻吩二甲醛 、 N,N-bis-(2-aminoethyl)-t-butylamine 、 tert-butylammonium hexafluorophosphate(V) 、 silver nitrate 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  衍生自2,5-二甲酰基噻吩的24元双臂四亚胺Schiff碱大环的双核银（I）配合物

  摘要：

  摘要由2,5-二甲酰基噻吩与胺N，N-双-（2-氨基乙基）-2-苯基乙胺，N，N-双环缩合衍生的双臂四亚胺席夫碱大环双核铜（I）配合物的合成描述了-（2-氨基乙基）-正丁胺和N，N-双-（2-氨基乙基）-叔丁胺。报道了三种这样的复合物的结构。复合物[Cu2L3（CH3CN）2]（PF6）2·CH3CN在单斜空间群P21 / c中结晶，晶胞尺寸为a = 15.897（4），b = 13.329（4），c = 21.999（5） A，β= 90.85（2）°，Z = 4；Cu-Cu的分离度为5.201A。[Cu2L4（CH3CN）2]（PF6）2·0.64CH3CN在单斜空间群P21 / n中结晶，晶胞尺寸为a = 17.243（5），b = 11.451 （6），c = 26.534（8）A，β= 100.08（2）°，Z = 4；Cu–Cu的间距为5.386A。复合物[Cu2L6（CH3C

  DOI：

  10.1016/s0020-1693(96)05220-6

文献信息

• ELASTIC POLYURETHANE-UREA FIBER AND PROCESS FOR PRODUCING THE SAME
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1170407A1

  公开（公告）日：2002-01-09

  An improved polyurethane-urea elastic fiber is obtained by incorporating a specific urea compound prepared by reacting the following compounds together: (a) a nitrogen-containing compound having both at least one bifunctional amine group selected from a group consisting of a primary amine group and a secondary amine group and at least one nitrogen-containing group selected from a group consisting of a tertiary nitrogen group and a heterocyclic nitrogen group; (b) an organic diisocyanate; and (c) at least one compound selected from the group consisting of a mono- or di-alkylmonoamine, an alkylmonoalcohol and an organic monoisocyanate. With the incorporation of the specific urea compound, the polyurethane-urea elastic fiber which can be fast dyed exhibits enhanced thermosettability and increased elastic functions can be produced through a stabilized spinning process. The improved thermosetting property enables end use products of the present fiber such as swimsuits and panty hose to be firmly shaped and to be substantially free from grinning.

  一种改进的聚氨酯-脲弹性纤维是通过加入一种特定的脲化合物而获得的，这种脲化合物是通过将下列化合物反应在一起而制备的： (a) 含氮化合物，该化合物具有至少一个双官能胺基团，该双官能胺基团选自由伯胺基团和仲胺基团组成的组，以及至少一个含氮基团，该含氮基团选自由叔氮基团和杂环氮基团组成的组； (b) 有机二异氰酸酯；和 (c) 至少一种选自单或双烷基单胺、烷基单醇和有机单异氰酸酯的化合物。 加入特定的脲化合物后，可通过稳定的纺丝工艺生产出具有更强热固性和更高弹性功能的可快速染色的聚氨酯-脲弹性纤维。改进后的热固性能使本纤维的最终产品（如泳衣和连裤袜）具有牢固的形状，并且基本上不会产生褶皱。
• Derivatives of amphotericin B
  申请人：Sfunga Therapeutics, Inc.

  公开号：US10882883B2

  公开（公告）日：2021-01-05

  Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I); C3′-substituted C16 ureas, carbamates, and amides according to Formula (II); C16 acyls according to Formula (III); C2′epi-C16 ureas, carbamates, and amides according to Formula (IV); and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.

  本发明公开了两性霉素B（AmB）的衍生物，其特点是与AmB相比，治疗指数有所提高。AmB衍生物包括根据式（I）的C16脲、氨基甲酸酯和酰胺；根据式（II）的C3′-取代的C16脲、氨基甲酸酯和酰胺；根据式（III）的C16酰基；根据式（IV）的C2′-环-C16脲、氨基甲酸酯和酰胺；以及根据式（V）的C16噁唑烷酮衍生物。还公开了包含AmB衍生物的药物组合物，以及使用AmB衍生物的治疗方法。
• Hybrid Amphotericin B derivatives with reduced toxicity
  申请人：The Board of Trustees of the University of Illinois

  公开号：US11198705B2

  公开（公告）日：2021-12-14

  Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.

  公开了两性霉素 B（AmB）的衍生物，其特点是与 AmB 相比，临床疗效提高，毒性降低。还公开了包含 AmB 衍生物的药物组合物、使用 AmB 衍生物的治疗方法和制造 AmB 衍生物的方法。
• Corrosion-indicating materials and methods of making and using the same
  申请人：Saudi Arabian Oil Company

  公开号：US11236195B2

  公开（公告）日：2022-02-01

  A corrosion-indicating material and methods of producing and using the corrosion-indicating material are provided. The corrosion-indicating material comprises a cured product of reacting a bisphenol A diglycidyl ether epoxy (DGEBA) resin with a curing agent, the curing agent comprising a 1,10-phenanthroline derivative having formula (I): where: R1 and R2 are independently selected from —NH2; —NH(CH2)aNH2, where a is 1, 2, or 3; —OC(═O)(CH2)bNH2, where b is 1, 2, or 3; and —H; R3 and R4 are either: non-joined monovalent radicals each independently chosen from —H, —NH2, and (C1-C20)heterohydrocarbyls comprising at least one primary amine or at least one secondary amine; or joined as a single divalent radical, the single divalent radical being a (C1-C40)heterohydrocarbyl comprising at least one primary amine or at least one secondary amine; and at least one of R1, R2, R3, and R4 is not —H.

  本文提供了一种腐蚀指示材料以及生产和使用该腐蚀指示材料的方法。腐蚀指示材料包括双酚 A 二缩水甘油醚环氧树脂（DGEBA）与固化剂反应的固化产物，固化剂包括具有式（I）的 1，10-菲罗啉衍生物： 其中R1和R2独立地选自-NH2；-NH(CH2)aNH2，其中a为1、2或3；-OC(═O)( )bNH2，其中b为1、2或3；和-H； R3和R4或者是各自独立选自-H、-NH2 和包含至少一个伯胺或至少一个仲胺的 (C1-C20)heterohydrocarbyl 的非连接单价基；或连接为单个二价基，该单个二价基为包含至少一个伯胺或至少一个仲胺的 (C1-C40)heterohydrocarbyl ；且 R1、R2、R3 和 R4 中至少有一个不是-H。
• REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT
  申请人：UNIVERSITY OF WOLLONGONG

  公开号：US20140221331A1

  公开（公告）日：2014-08-07

  The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.