[Mn(S₂CNEt₂)₃] | 15740-71-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [Mn(S₂CNEt₂)₃]
• 英文别名: tris(N,N-diethyldithiocarbamato)manganese(III)；tris(N,N-diethyldithiocarbamate)manganese；[Mn(III)(N,N-diethyldithiocarbamate-S,S')3]；[Mn(dtc)3]；N,N-diethylcarbamodithioate;manganese(3+)
• CAS: 15740-71-3
• 化学式: C₁₅H₃₀MnN₃S₆
• 分子量: 499.757
• InChiKey: CUTOCNKWXFZJSY-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  3.48
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [Mn(S₂CNEt₂)₃] 在 HCl 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 生成 manganese(III) (diethyl dithiocarbamate)2Cl
  参考文献：
  名称：

  Kanungo, B. K.; Pradhan, B.; Rao, D. V. Ramana, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical

  摘要：

  DOI：
• 作为产物：
  描述：

  μ-oxo-[bis(diethyldithiocarbamato)oxomolybdenum(V)][bis(diethyldithiocarbamato)manganese(II)] monohydrate 在 air 作用下， 以 丙酮 为溶剂， 生成 [Mn(S₂CNEt₂)₃]
  参考文献：
  名称：

  Elliott, Robyn L.; Nichols, Peter J.; West, Bruce O., Australian Journal of Chemistry, 1986, vol. 39, p. 975 - 986

  摘要：

  DOI：

文献信息

• The synthesis and characterisation of [Pd(S2CNEt2)(Ph2PCH2CH2PPh2]+ salts of some chloro- and bromo-metallate anions—X-ray crystal structures of [Pd(S2CNEt2)(Ph2PCH2CH2PPh2)+[MCl2]− (M = Cu, Ag)
  作者：George Exarchos、Stanley C Nyburg、Stephen D Robinson

  DOI：10.1016/s0277-5387(97)00386-0

  日期：1998.1

  dithiocarbamates) [M(S2CNR2)2] (M = Pb, Zn, Cd, Hg, Cu, Ni, MoO2, VO; R = Et, Bun), in refluxing dicloromethane, to afford the known complexes [|PdCl(S2CNR2)|2] in virtually quantitative yield. In boiling acetonitrile the diphosphine complexes [PdX2(Ph2PCH2CH2PPh2)] (X = Cl, Br) react readily with bi- and trivalent metal diethyl dithiocarbamates [M(S2CNEt2)n] (M = Pb, Zn, Cd, Hg. Ni, MoO2, VO n = 2; M = Co, Fe

  钯配合物[PdCl 2（PhCN）2 ]容易与金属双（二烷基二硫代氨基甲酸酯）[M（S 2 CNR 2）2 ]反应（M = Pb，Zn，Cd，Hg，Cu，Ni，MoO 2，VO； R = Et，Bu n），在回流的二氯甲烷中，得到已知的络合物[| PdCl（S 2 CNR 2）|。2 ]几乎定量的产率。在沸腾的乙腈中，二膦配合物[PdX 2（Ph 2 PCH 2 CH 2 PPh 2）]（X = Cl，Br）容易与二价和三价金属二乙基二硫代氨基甲酸酯[M（S 2CNEt 2）n ]（M = Pb，Zn，Cd，Hg。Ni ，MoO 2，VO n = 2; M = Co，Fe，Mn，n = 3）得到通式[Pd（S 2 CNEt 2）（Ph 2 PCH 2 CH 2 PPh 2）] 2 + [MX 4 ] 2-。铜（II）和银（I）的二乙基二硫代氨基甲酸酯形成[Pd（S 2 CNEt 2）（Ph
• The synthesis of new bimetallic complex salts by halide/sulfur chelate cross transfer: X-ray crystal structures of the salts [Ni(S2CNEt2)(dppe)]2[HgBr4], [Pt(S2CNEt2)(dppe)]2[CdCl4], [Co(S2CNEt2)2(dppe)]2[Cl3ZnO:(Ph)2PCH2CH2P(Ph)2:OZnCl3] and [Pd(S2CNnBu2)(bipy)]2[CdCl4]
  作者：George Exarchos、Stephen D Robinson、Jonathan W Steed

  DOI：10.1016/s0277-5387(01)00885-3

  日期：2001.11

  [Zn(S2CNEt2)2] in the presence of (S2CNEt2)2 affords the novel complex [Co(S2CNEt2)2(dppe)]2[Cl3ZnO:(Ph)2PCH2CH2P(Ph)2:OZnCl3]. A selection of these salts have been fully characterised by elemental analysis and spectroscopic techniques, the remainder have been identified by spectroscopic methods alone. X-ray crystal structures are reported for the salts [Ni(S2CNEt2)(dppe)]2 [HgBr4], [Pt(S2CNEt2)(dppe)]2[CdCl4]

  摘要镍和铂配合物[MX2（dppe）]（X = Cl，Br）与二价和三价金属二乙基二硫代氨基甲酸酯[M'（S2CNEt2）n]（M'= Pb，Zn，Cd，Hg，Ni ，MoO 2，VO，n ＝ 2； M′＝ Co，Fe，Mn，n ＝ 3）得到盐[M（S 2 CNEt 2）（dppe）] 2 [M′X 4]；涉及[Cu（S2CNEt2）2]和[Ag（S2CNEt2）]的反应生成的盐形式为[M（S2CNEt2）（dppe）] [M'X2]（M'= Cu，Ag）。顺式[RuCl2（dppm）2]，[CoCl2（dppe）]和[PdX2（bipy）]络合物同样与相同的二硫代氨基甲酸酯反应形成盐[Ru（S2CNEt2）（dppe）2] 2 [M'Cl4] [ Co（S2CNEt2）2（dppe）] 2 [M'Cl4]和[Pd（S2CNnBu2）（bipy）] 2 [M'X4]。涉及其他S-螯合物的配
• Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation
  作者：Petra Martini、Alessandra Boschi、Lorenza Marvelli、Licia Uccelli、Stefano Carli、Giuseppe Cruciani、Erika Marzola、Anna Fantinati、Juan Esposito、Adriano Duatti

  DOI：10.3390/molecules26195954

  日期：——

  However, manganese complexes with dithiocarbamates, to our knowledge, have never been used for medical imaging applications. With the aim of developing a new class of mononuclear manganese(II)-based agents for molecular imaging applications, we performed a specific investigation into the synthesis of mononuclear bis-substituted Mn(II) complexes with dithiocarbamate ligands. (2) Methods: Synthesis in either

  (1) 背景：金属二硫代氨基甲酸酯化合物由于其易于形成、优异的性能和潜在的应用，长期以来一直是研究的主题。然而，据我们所知，锰与二硫代氨基甲酸盐的配合物从未用于医学成像应用。为了开发用于分子成像应用的新型单核锰 (II) 基试剂，我们对具有二硫代氨基甲酸酯配体的单核双取代锰 (II) 配合物的合成进行了具体研究。(2)方法：在不同的Mn(II)与二乙基二硫代氨基甲酸酯的摩尔比下在开放或惰性气氛中进行合成，并通过IR、EA、ESI-MS和XRD分析表征产物。(3) 结果：我们发现只有在无氧大气条件下，Mn(II) 络合物 MnL获得了图2，其中L=二乙基二硫代氨基甲酸酯配体，进一步观察到其与固态分子氧反应以形成中间体超氧合Mn(III)络合物[MnL 2 (η 2 -O 2 )]。质谱揭示了超氧配合物的存在，该物种被解释为导致双取代 Mn(II) 配合物 MnL 2转化为三取代 Mn(III)的反应的中间步骤复合物，MnL
• The synthesis and characterisation of [Pd(S2CNEt2){Ph2P(CH2)nPPh2}]+ salts of some chlorometallate anions (n=1, 3, 4): X-ray crystal structures of the salts [Pd(S2CNEt2){Ph2P(CH2)nPPh2}]2[MCl4] (n=1, 4; M=Cd; n=3; M=Hg)
  作者：George Exarchos、Stephen D Robinson、Jonathan W Steed

  DOI：10.1016/s0277-5387(00)00415-0

  日期：2000.6

  palladium complexes [PdCl2Ph2P(CH2)nPPh2}] (n=1, 3, 4) react with the bi- and tri-valent metal diethyldithiocarbamates [M(S2CNEt2)2] (M=Zn, Cd, Hg, Pb) and [Mn(S2CNEt2)3] in cold dichloromethane solution to afford salts of the general form [Pd(S2CNEt2)Ph2P(CH2)nPPh2}]2[MCl4] in almost quantitative yield. X-ray crystal structures are reported for the salts [Pd(S2CNEt2)Ph2P(CH2)nPPh2}]2[MCl4] (n=1, 4; M=Cd:

  钯配合物[PdCl 2 Ph 2 P（CH 2）n PPh 2 }]（n = 1，3，4 ）与二价和三价金属二乙基二硫代氨基甲酸酯[M（S 2 CNEt 2）2 ]（在二氯甲烷溶液中加入M = Zn，Cd，Hg，Pb）和[Mn（S 2 CNEt 2）3 ]得到通式[Pd（S 2 CNEt 2）Ph 2 P（CH 2）n PPh ]的盐2 }] 2 [MCl 4]几乎定量的产量。报道了盐[Pd（S 2 CNEt 2）Ph 2 P（CH 2）n PPh 2 }] 2 [MCl 4 ]（n = 1，4; M = Cd：n = 3 ）的X射线晶体结构，M ＝ Hg）。将这些盐的结构参数，IR和NMR光谱数据与先前报道的相关阳离子[Pd（S 2 CNEt 2）Ph 2 P（CH 2）2 PPh 2 }] +盐的相似数据进行比较。
• Synthetic and Nanotechnological Approaches for a Diagnostic Use of Manganese
  作者：Maddalena Sguizzato、Petra Martini、Lorenza Marvelli、Walter Pula、Markus Drechsler、Martina Capozza、Enzo Terreno、Lucia Del Bianco、Federico Spizzo、Rita Cortesi、Alessandra Boschi

  DOI：10.3390/molecules27103124

  日期：——

  The development of multimodal imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) allows the contemporary obtaining of metabolic and morphological information. To fully exploit the complementarity of the two imaging modalities, the design of probes displaying radioactive and magnetic properties at the same time could be very beneficial. In this regard, transition metals offer appealing options, with manganese representing an ideal candidate. As nanosized imaging probes have demonstrated great value for designing advanced diagnostic/theranostic procedures, this work focuses on the potential of liposomal formulations loaded with a new synthesized paramagnetic Mn(II) chelates. Negatively charged liposomes were produced by thin-layer hydration method and extrusion. The obtained formulations were characterized in terms of size, surface charge, efficiency of encapsulation, stability over time, relaxivity, effective magnetic moment, and in vitro antiproliferative effect on human cells by means of the MTT assay. The negatively charged paramagnetic liposomes were monodisperse, with an average hydrodynamic diameter not exceeding 200 nm, and they displayed good stability and no cytotoxicity. As determined by optical emission spectroscopy, manganese complexes are loaded almost completely on liposomes maintaining their paramagnetic properties.

  正电子发射断层扫描（PET）和磁共振成像（MRI）等多模态成像技术的发展，使我们能够在当代获取代谢和形态信息。为了充分利用这两种成像模式的互补性，设计同时具有放射性和磁性的探针将大有裨益。在这方面，过渡金属提供了有吸引力的选择，其中锰是理想的候选材料。由于纳米级成像探针在设计先进的诊断/止血程序方面已显示出巨大的价值，这项工作的重点是研究装载了新合成的顺磁性锰（II）螯合物的脂质体制剂的潜力。通过薄层水合法和挤压法制备了带负电荷的脂质体。所获得的制剂在尺寸、表面电荷、包封效率、长期稳定性、弛豫性、有效磁矩以及通过 MTT 试验对人体细胞的体外抗增殖作用等方面都具有特征性。带负电荷的顺磁脂质体呈单分散状态，平均流体力学直径不超过 200 nm，稳定性好，无细胞毒性。根据光学发射光谱测定，锰复合物几乎完全负载在脂质体上，保持了其顺磁性能。