2-hydroxy-1-naphthaldehyde-6-carboxylic acid | 62419-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxy-1-naphthaldehyde-6-carboxylic acid
• 英文别名: 5-formyl-6-hydroxy-2-naphthoic acid；1-formyl-2-hydroxy-6-naphthoic acid；1-Formyl-2-hydroxynaphthalin-6-carbonsaeure；5-Formyl-6-hydroxynaphthalene-2-carboxylic acid
• CAS: 62419-31-2
• 化学式: C₁₂H₈O₄
• 分子量: 216.193
• InChiKey: KCUNIKPYRZUEHV-UHFFFAOYSA-N

物化性质

• 沸点：
  420.9±30.0 °C(Predicted)
• 密度：
  1.478±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴代硝基甲烷 、 2-hydroxy-1-naphthaldehyde-6-carboxylic acid 在 potassium fluoride 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以58%的产率得到2-硝基苯并[e][1]苯并呋喃-7-羧酸
  参考文献：
  名称：

  Einhorn; Lamotte; Buisson, European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 143 - 147

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基-6-萘甲酸 、 溶剂黄146 在 乌洛托品 、 硫酸 作用下， 反应 0.5h， 生成 2-hydroxy-1-naphthaldehyde-6-carboxylic acid
  参考文献：
  名称：

  Efficient adsorption of organic dyes by two porous heterometallic metal–organic frameworks assembled with Schiff base ligands and Fe3+/Cd2+ ions

  摘要：

  Two porous heterometallic metal-organic frameworks (HMOFs), [Cd-2(Fe-L1)(2)(mu(2)-O)(H2O)(2)]center dot 4DMF center dot MeOH center dot 2H(2)O (1), and [Cd-2(Fe-L2)(2)(mu(2)-O)(H2O)(2)]center dot 3DMF (2) (H(4)L1 = N,N'-cyclohexanediaminebis(2-hydroxyl-6-carboxy-1-naphthaldehy) and H4L2 = N,N'-o-phenylenediaminebis-(2-hydroxyl-6-carboxy-1-naphthaldehy) have been synthesized and characterized under solvothermal conditions. Both HMOFs feature porous 3D frameworks constructed from square-pyramidal coordinated Fe3+ ions, [Cd-4(COO)(8)(H2O)(4)] tetranucler clusters and Schiff base anions. However, 1 and 2 have different cavities because of the different coordination modes and spatial orientations of L1(4-) and L2(4-) anions. The adsorption performance of 1 and 2 towards eight organic dyes in aqueous solutions had been investigated. The result shows that 1 exhibits better adsorption ability than 2. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2018.09.038

文献信息

• Signal transduction inhibitors, compositions containing them
  申请人：Ariad Pharmaceuticals, Inc.

  公开号：US06576766B1

  公开（公告）日：2003-06-10

  This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutic compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (1) as defined herein.

  这项发明涉及用于抑制细胞内信号传导的化合物，特别是通过涉及磷酸酪氨酸含蛋白质的一种或多种分子相互作用介导的细胞内信号传导。该发明还涉及含有这些化合物的药物组合物，以及涉及这些化合物的预防和治疗方法，包括药物和兽医用途中的给药。这些化合物的化学式如本文所定义。
• EINHORN, J.;LAMOTTE, G.;BUISSON, J. -P.;DEMERSEMAN, P.;ROYER, R.;CAVIER, +, EUR. J. MED. CHEM., 1984, 19, N 2, 143-147
  作者：EINHORN, J.、LAMOTTE, G.、BUISSON, J. -P.、DEMERSEMAN, P.、ROYER, R.、CAVIER, +

  DOI：——

  日期：——
• NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：EP1030853A1

  公开（公告）日：2000-08-30
• HETEROCYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：EP1064289A1

  公开（公告）日：2001-01-03
• US4064349A
  申请人：——

  公开号：US4064349A

  公开（公告）日：1977-12-20