3-Chlor-2-methyl-pentan | 38384-05-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 3-Chlor-2-methyl-pentan
• 英文别名: 3-Chloro-2-methylpentane
• CAS: 38384-05-3
• 化学式: C₆H₁₃Cl
• 分子量: 120.622
• InChiKey: FCPXHGJZKRXGJY-UHFFFAOYSA-N

物化性质

• 沸点：
  117.7±8.0 °C(Predicted)
• 密度：
  0.863±0.06 g/cm3(Predicted)
• 保留指数：
  845;850;862

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-ethyl-3-methyl-butyryl chloride 在 四氯化碳 、 4-二甲氨基吡啶 、 2-mercaptopyridine-1-oxide sodium salt 作用下， 反应 3.0h， 以88%的产率得到3-Chlor-2-methyl-pentan
  参考文献：
  名称：

  Stofer, Edmond; Lion, Claude, Bulletin des Societes Chimiques Belges, 1987, vol. 96, # 8, p. 623 - 628

  摘要：

  DOI：

文献信息

• Survival of Women with Breast Cancer in Relation to Smoking
  作者：Jonas Manjer

  DOI：10.1080/110241500447227

  日期：2000.10.20

  ObjectiveTo compare survival of patients with breast cancer who had never smoked, were smokers, and who were ex-smokers.DesignObservational study.SettingCity of Malmö, Sweden.Patients792 patients with breast cancer diagnosed between 1977–1986 in the Malmö mammographic screening trial.InterventionsFollow-up of breast cancer cases through record-linkage with the Swedish Cause of Death Registry.Main outcome measuresDeath from breast cancer. Relative risk (RR) with 95% confidence interval (CI) of death from breast cancer was calculated for different smoking groups using Cox's proportional hazards analysis.ResultsDuring a mean follow-up of 12.1 years, 145 patients died of breast cancer. Breast cancer mortality was 1347/105 person-years in those who had never smoked, 1941/105 in smokers, and 1493/105 in ex-smokers. The crude RR for smokers and ex-smokers, compared with those who had never smoked were 1.44 (1.01 to 2.06) and 1.13 (0.66 to 1.94), respectively. The RR associated with smoking remained significant after adjustment for age and stage at diagnosis, 2.14 (1.47 to 3.10), and other potential confounders.ConclusionsSurvival after breast cancer was, as expected, strongly related to stage at diagnosis. However, stage by stage there was considerable variation between individual patients. We conclude that differences with regard to exposure to smoking contribute to this heterogeneity.

  Objective 旨在比较从未吸烟、吸烟和已戒烟的乳腺癌患者的生存情况。Design 这是一项观察性研究。Setting 研究地点位于瑞典马尔默市。Patients 研究对象为1977年至1986年间在马尔默乳腺筛查试验中被诊断为乳腺癌的792名患者。Interventions 通过与瑞典死因登记库的记录关联，对乳腺癌病例进行随访。Main outcome measures 主要观察指标是死于乳腺癌的情况。利用Cox比例风险分析计算不同吸烟群体死于乳腺癌的相对风险（RR）及其95%置信区间（CI）。Results 在平均12.1年的随访期间，145名患者死于乳腺癌。从未吸烟者、吸烟者和已戒烟者的乳腺癌死亡率分别为每10万人年1347例、1941例和1493例。与从未吸烟者相比，吸烟者和已戒烟者的粗略相对风险分别为1.44（1.01至2.06）和1.13（0.66至1.94）。在调整年龄和诊断分期以及其他潜在混杂因素后，与吸烟相关的相对风险仍然显著，为2.14（1.47至3.10）。Conclusions 如预期的那样，乳腺癌后的生存强烈依赖于诊断时的分期。然而，各分期之间个体患者的生存情况存在显著差异。我们得出结论，关于吸烟暴露的差异对此异质性有贡献。
• Transition metal compound, polymerization-initiator system comprising the same, and process for producing polymer
  申请人：Uemura Makoto

  公开号：US20070270521A1

  公开（公告）日：2007-11-22

  A transition metal compound represented by the formula, [(CpR 1 m )(CO) 2 M 1 ][M 2 (CO) 2 (CpR 2 n )], wherein Cp is a cyclopentadienyl ring, R 1 and R 2 are independently of each other a hydrocarbyl group having 1 to 20 carbon atoms, and each of at least one R 1 and at least one R 2 is a hydrocarbyl group having 5 to 20 carbon atoms, m and n are independently of each other an integer of 1 to 5, and M 1 and M 2 are independently of each other a transition metal atom of the group 8 in the periodic table of elements; a polymerization-initiator system comprising said transition metal compound; and a process for producing a polymer in the presence of the polymerization-initiator system.

  一个由该公式表示的过渡金属化合物，[(CpR1m)(CO)2M1][M2(CO)2(CpR2n)]，其中Cp是一个环戊二烯环，R1和R2是独立的烃基团，含有1至20个碳原子，至少一个R1和至少一个R2是含有5至20个碳原子的烃基团，m和n是独立的1至5的整数，M1和M2是元素周期表中8族的过渡金属原子；包括所述过渡金属化合物的聚合物化引发剂系统；以及在聚合物化引发剂系统存在的情况下生产聚合物的过程。
• [EN] PROCESS FOR PREPARING SULFIMINES AND THEIR IN-SITU CONVERSION INTO N-(2-AMINO-BENZOYL)-SULFIMINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE SULFIMINES ET LEUR CONVERSION IN SITU EN N-(2-AMINO-BENZOYL)SULFIMINES
  申请人：BASF SE

  公开号：WO2014154807A1

  公开（公告）日：2014-10-02

  The present invention relates to a process for preparing a compound of the formulae (la) or (lb), or a mixture thereof, wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; A- is HSO4- or 1/2 SO42-; the process comprising the reaction of a sulfide of formula SR1R2 with hydroxylamine- O-sulfonic acid of formula; wherein the reaction is carried out in an aqueous medium in the presence of a base. The present invention also relates to a process for preparing a compound of the formula (IV), wherein R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8- halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; p is 0, 1, 2, 3 or 4; the process comprising: (i) providing the compound of the formulae (la) or (lb), or a mixture thereof, (ii) reacting a compound of the formulae (la) or (lb), or a mixture thereof, obtained in step (i) with a compound of the formula (V) in the presence of a base,

  本发明涉及制备公式（la）或（lb）化合物或其混合物的过程，其中R1和R2分别独立地是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C10-环烷基，C3-C10-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基或者一起代表脂肪链等；A-是HSO4-或1/2 SO42-；该过程包括将公式SR1R2的硫化物与公式的羟胺-O-磺酸反应；其中在碱的存在下在水介质中进行反应。本发明还涉及一种制备公式（IV）化合物的过程，其中R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基或类似物；R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基或类似物；p为0、1、2、3或4；该过程包括：（i）提供公式（la）或（lb）化合物或其混合物；（ii）在碱的存在下，将步骤（i）中获得的公式（la）或（lb）化合物或其混合物与公式（V）的化合物反应。
• Removal of chlorinated hydrocarbons from alkylsilanes
  申请人：DOW CORNING CORPORATION

  公开号：EP0331123A2

  公开（公告）日：1989-09-06

  A process for reducing the chlorocarbon content of alkylsilanes is described. The process comprises (A) contacting crude alkylsilanes, containing as a minor portion chlorocarbons and a hydrogen-containing silane with a catalyst; wherein the catalyst is a sufficient amount of an effective Lewis acid forming material; (B) facilitating the reaction of the chlorocarbons with the hydrogen-containing silane in contact with the catalyst to convert the chloro­carbons to a linear or branched alkanes; (C) separating catalyst from the alkylsilanes and alkanes; and (D) recovering alkylsilanes with lowered chlorocarbon content.

  描述了一种减少烷基硅烷中碳氯含量的工艺。该工艺包括：(A) 将含有少量碳酰氯和含氢硅烷的粗烷基硅烷与催化剂接触；其中催化剂是足量的有效路易斯酸形成材料；(B) 促进碳酰氯与含氢硅烷在与催化剂接触时发生反应，将碳酰氯转化为线性或支链烷烃；(C) 从烷基硅烷和烷烃中分离催化剂；(D) 回收碳酰氯含量降低的烷基硅烷。
• Method for redistribution and purification of methylsilanes
  申请人：DOW CORNING CORPORATION

  公开号：EP0743315A2

  公开（公告）日：1996-11-20

  A redistribution process for enriching a low-boiling methylsilane mixture in a methylchlorosilane selected from dimethylhydrochlorosilane and trimethylchlorosilane. The process comprises contacting a low-boiling methylsilane mixture, resulting from the contact of methyl chloride with silicon, with alumina under non-equilibrium conditions at a temperature greater than 150°C. we have surprisingly found that the concentrations of dimethylhydrochlorosilane and trimethylchlorosilane reach maximum levels under non-equilibrium conditions occurring at a temperature greater than 150°C. The process is also useful for facilitating the removal of olefin and chlorocarbon organic contaminants from the low-boiling methylsilane mixture.

  一种使低沸点甲基硅烷混合物富含选自二甲基氢氯硅烷和三甲基氯硅烷的甲基氯硅烷的再分配工艺。我们惊奇地发现，在温度高于 150°C 的非平衡条件下，二甲基氢氯硅烷和三甲基氯硅烷的浓度达到最大值。该工艺还有助于从低沸点甲基硅烷混合物中去除烯烃和碳酰氯有机污染物。