2-bromomethyl-9-methyl-1,10-phenanthroline | 122637-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2-bromomethyl-9-methyl-1,10-phenanthroline
• 英文别名: 2-(bromomethyl)-9-methyl-1,10-phenanthroline
• CAS: 122637-42-7
• 化学式: C₁₄H₁₁BrN₂
• 分子量: 287.159
• InChiKey: GPURSUXESGDBGT-UHFFFAOYSA-N

物化性质

• 沸点：
  417.4±40.0 °C(Predicted)
• 密度：
  1.512±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromomethyl-9-methyl-1,10-phenanthroline 在 sodium carbonate 作用下， 以80%的产率得到(9-甲基-1,10-菲咯啉-2-基)甲醇
  参考文献：
  名称：

  摘要：

  The synthesis and crystal structure of a luminescent dinuclear Cu(I) complex as the BF4- salt from toluene and methanol containing triphenylphosphine and mu-oxo-bis(2,9-dimethyl-1,10-phenanthroline) is described. The coordination geometry about the Cu(I) center is distorted tetrahedral. An unusual feature of the structure is a pseudo-inversion center located near the oxygen atom at approximately 0.51, 0.26, 0.25, such that all of the atoms except for the oxygen are related by a pseudo-inversion center to another atom in the same molecule, as well as by crystallographic inversion to the other molecule in the unit cell. The complex displays luminescence from an MLCT band in fluid solution and emission from both a metal-centered charge-transfer and intraligand (phenanthroline) state at 77K in a chloroform snow. Crystal data: triclinic, P(1)over bar, a = 15.163(2), b = 16.985(2), c = 18.731(2) Angstrom, alpha = 106.458(9), beta = 91.416(8), gamma = 102.557(9)degrees, V = 4496(1) Angstrom(3), and Z = 2.

  DOI：

  10.1023/a:1009595720117
• 作为产物：
  描述：

  新铜试剂 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 8.0h， 以73%的产率得到2-bromomethyl-9-methyl-1,10-phenanthroline
  参考文献：
  名称：

  一种四齿配体及金属络合物及其制备方法和应用

  摘要：

  本发明公开了一种由通式(1)所示的新型含有吡啶基SNNN四齿配体L，和包含该SNNN四齿配体L的金属络合物MXY(L)，及其制备方法，以及采用该金属络合物MXY(L)的由酯类化合物的催化氢化制备醇类化合物的方法。本发明利用含有‑NH‑基团在酯氢化过程中与金属H的协同作用提高催化剂的反应活性，另一方面，由于吡啶基团、硫原子(S)具有强的配位能力、富电子性质，使得中心金属更加富电子，催化剂活性提高；同时由于吡啶基团、硫原子(S)相对膦配体(P)对空气、水更加稳定，且由于前述四齿配体SNNN与金属钌盐形成四齿配合物，该配合物具有更高稳定性，使得催化剂在反应条件下具有更高的稳定性、更长使用寿命及更高的催化剂转化数(TON)。#imgabs0#

  公开号：

  CN114436949B

文献信息

• Polypyridine Fluorescent labels for immunoassay
  申请人：Eastman Kodak Company

  公开号：US04837169A1

  公开（公告）日：1989-06-06

  There are described stable fluorescent labels comprising a complex of Eu.sup.+3 and a chelating agent comprising a nucleus which is a triplet sensitizer having a triplet energy greater than that of Eu.sup.+3 and at least two heteroatom-containing groups which form coordinate complexes with Eu.sup.+3 and a third heteroatom-containing group or heteroatom in or appended to the triplet sensitizer. Labeled physiologically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, hormones and the like comprising the stable fluorescent labels having physiologically active materials adsorbed or bonded thereto are also described.

  本文描述了稳定的荧光标记物，其中包括Eu.sup.+3和螯合剂的复合物，该螯合剂包括一个三重态敏化剂核，其三重态能量大于Eu.sup.+3，并且至少有两个含杂原子的基团与Eu.sup.+3形成配位络合物，以及第三个杂原子含量的基团或附加到三重态敏化剂中的杂原子。还描述了用于特定结合分析的标记生理活性材料，例如标记的抗原、半抗原、抗体、激素等，其中包括吸附或与稳定荧光标记物结合的生理活性材料。
• Terpyridine chelating agents
  申请人：Eastman Kodak Company

  公开号：US04859777A1

  公开（公告）日：1989-08-22

  There are described stable fluorescent labels comprising a complex of Eu.sup.+3 and a chelating agent comprising a nucleus which is a triplet sensitizer having a triplet energy greater than that of Eu.sup.+3 and at least two heteroatom-containing groups which form coordinate complexes with Eu.sup.+3 and a third heteroatom-containing group or heteroatom in or appended to the triplet sensitizer. Labeled physiologically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, hormones and the like comprising the stable fluorescent labels having physiologically active materials adsorbed or bonded thereto are also described.

  描述了稳定的荧光标记物，包括Eu.sup.+3和螯合剂的复合物，其中螯合剂包括一个三重态敏化剂的核，其三重态能量大于Eu.sup.+3，并且至少有两个含杂原子的基团与Eu.sup.+3形成配位络合物，以及第三个含杂原子的基团或杂原子附加到三重态敏化剂上。还描述了标记的生理活性物质，用于特定结合测定，如标记的抗原、半抗原、抗体、激素等，其中包括吸附或结合到稳定荧光标记物上的生理活性物质。
• Fluorescent labels
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0288256A2

  公开（公告）日：1988-10-26

  There are described stable fluorescent labels comprising a complex of Eu⁺³ and a chelating agent comprising a nucleus which is a triplet sensi­tizer having a triplet energy greater than that of Eu⁺³ and at least two heteroatom-containing groups which form coordinate complexes with Eu⁺³ and a third heteroatom-containing group or heteroatom in or appended to the triplet sensitizer which chelating agents are polypyridine or phenanthroline compounds. Labeled physio- logically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, hormones and the like comprising the stable fluores-cent labels having physiologically active materials adsorbed or bonded thereto are also described.

  所述的稳定荧光标签由 Eu⁺³和螯合剂复合物组成，螯合剂包括一个核，该核是三重能敏化剂，其三重能大于 Eu⁺³的三重能，以及至少两个含杂原子的基团，这些基团与 Eu⁺³形成配位复合物，以及三重能敏化剂中或附加在三重能敏化剂上的第三个含杂原子的基团或杂原子，螯合剂是聚吡啶或菲罗啉化合物。此外，还描述了在特定结合试验中有用的标记生理活性材料，如标记抗原、抗原、抗体、激素等，这些材料包括吸附或结合有生理活性材料的稳定荧光标记。
• 一种铕配合物及其制备方法与应用
  申请人：华东理工大学

  公开号：CN115724856A

  公开（公告）日：2023-03-03

  本发明公开了一种铕配合物，是由式I或式II所示化合物与Eu配合形成的Eu配合物， 本发明的铕配合物是以1,4,7‑三氮杂环壬烷衍生物作为阳离子配体，该配体来源于金属螯合配体，与铕配合物的结合力强，稳定高；本发明的铕配合物可以用于制备微球填料。
• Casnati, A.; Fischer, C.; Guardigli, M., Journal of the Chemical Society. Perkin transactions II, 1996, # 3, p. 395 - 400
  作者：Casnati, A.、Fischer, C.、Guardigli, M.、Isernia, A.、Manet, I.、et al.

  DOI：——

  日期：——