2-methyl-N-propylpropan-1-imine | 2875-39-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-N-propylpropan-1-imine
• 英文别名: N-(2-methylpropylidene)propan-1-amine；Isobutyraldehyd-propylimid；N-Propyl-isobutyraldimin；isobutylidene-propyl-amine；Isobutyraldehyd-propylimin；Isobutyliden-propyl-amin；(Pr)NCH(i-Pr)
• CAS: 2875-39-0
• 化学式: C₇H₁₅N
• 分子量: 113.203
• InChiKey: FXZGBMRKYCVNIA-UHFFFAOYSA-N

物化性质

• 沸点：
  108-114 °C
• 密度：
  0.7456 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-N-propylpropan-1-imine 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 丙基异丁胺
  参考文献：
  名称：

  Notes - The Preparation of Secondary Aliphatic Amines from Schiff Bases Using Lithium Aluminum Hydride

  摘要：

  DOI：

  10.1021/jo01110a612
• 作为产物：
  描述：

  正丙胺 、 异丁醛 在 magnesium sulphate trihydrate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以97%的产率得到2-methyl-N-propylpropan-1-imine
  参考文献：
  名称：

  锌（II）催化的醛亚胺和酮亚胺与炔烃的偶联合成炔丙胺

  摘要：

  已证明衍生自未活化醛或酮，伯胺或α-氨基酸酯的亚胺与各种末端炔烃进行Zn II催化反应，生成具有三或四取代α-碳原子的仲炔丙胺（来自醛亚胺和ketimines）。

  DOI：

  10.1002/ejoc.201701567

文献信息

• Synthesis of highly functionalized 1,6-dihydropyridines <i>via</i> the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)
  作者：Syeda Aaliya Shehzadi、Christophe M. L. Vande Velde、Aamer Saeed、Kourosch Abbaspour Tehrani

  DOI：10.1039/c8ob00195b

  日期：——

  three component synthesis of 1,6-dihydropyridines, involving aldimines, alkynes and electron-deficient dimethyl acetylenedicarboxylate (DMAD), in good to excellent yields has been described. Besides a range of different N-substituents, a variety of both aromatic and aliphatic alkynes could be used. The application of electron-deficient propiolates instead of DMAD resulted in regiospecific incorporation

  已经描述了三氟甲磺酸锌（II）催化1，6-二氢吡啶的三组分合成，涉及醛亚胺，炔烃和电子缺陷的乙炔基二羧酸二甲酯（DMAD），收率良好至优异。除了一系列不同的N-取代基之外，还可以使用多种芳族和脂族炔烃。缺电子的丙酸酯代替DMAD的应用导致在1,6-二氢吡啶环上酯官能团的区域特异性结合。该反应通过级联反应进行，该级联反应包括将乙炔金属亲核加成到亚胺中，然后将中间形成的炔丙基胺加到缺电子的炔烃中，然后进行6-内挖。 环化。
• Reactions of Ruthenium Benzylidene Complexes with Cyclic and Acyclic Imines:  Oligomerization of 1-Pyrroline and Metathesis via Tautomerism
  作者：Jubo Zhang、T. Brent Gunnoe

  DOI：10.1021/om0301029

  日期：2003.5.1

  ring-opening oligomerization of the cyclic imine. The combination of ruthenium carbene complexes (Cl)2(PCy3)2RuCHPh and (Cl)2(PCy3)(H2IMes)RuCHPh (H2IMes = 1,3-dimesityl-4,5-dihydroimidazolylidene) with acyclic imines of the type (R)NCH(R‘) results in metathesis reactions when the imine possesses a C−H bond α to the imine carbon. Imines that lack C−H bonds α to the imine carbon do not react with (Cl)2(PCy3)2RuCHPh

  在室温下，NMR光谱表明钌亚苄基配合物（Cl）2（PCy 3）2 Ru CHPh与1-吡咯啉反应生成（Cl）2（PCy 3）（1-pyrroline）Ru CHPh。将（Cl）2（PCy 3）2 Ru CHPh与过量的1-吡咯啉溶液加热到90°C，会导致环状亚胺的开环低聚。钌卡宾配合物（Cl）2（PCy 3）2 Ru CHPh和（Cl）2（PCy 3）（H 2 IMes）Ru CHPh（H 2IMes =（R）N CH（R'）类型的无环亚胺的1，3-二甲磺基-1,4,5-二氢咪唑基亚甲基）会在亚胺对亚胺碳具有CH键的情况下发生复分解反应。在亚胺碳上缺少CH键的亚胺不会与（Cl）2（PCy 3）2 Ru CHPh反应。（Cl）2（PCy 3）2 Ru CHPh和（Cl）2（PCy 3）（H 2 IMes）Ru CHPh与无环亚胺反应的主要产物是烯烃和（Cl）类型的新Fischer卡宾络合物2（L）（L'）Ru
• Fick,F.-G.; Hartke,K., Chemische Berichte, 1976, vol. 109, p. 3929 - 3938
  作者：Fick,F.-G.、Hartke,K.

  DOI：——

  日期：——
• Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria
  作者：George Jerums、Terri J. Allen、Duncan J. Campbell、Mark E. Cooper、Richard E. Gilbert、Jeremy J. Hammond、Jan Raffaele、Con Tsalamandris

  DOI：10.1016/s0272-6386(05)80003-4

  日期：2001.5

  The aim of this study is to compare the efficacy of an angiotensin-converting enzyme inhibitor with a dihydropyridine calcium channel blocker in preventing progression to macroalbuminuria and/or a decline in renal function in normotensive patients with type 1 diabetes and microalbuminuria. Forty-two patients were randomized to treatment with either perindopril, slow-release nifedipine, or placebo. In the first 3 months, drug dosage was titrated to achieve a decrease in diastolic blood pressure of at least 5 mm Hg. Thirty-three patients had a minimum of 24 months' data, and 25 patients were followed up beyond 36 months (mean, 67 +/- 4 months). Patients were studied every 3 months and at the end of the treatment period; those who remained normotensive discontinued therapy and were followed up for an additional 3 months. Baseline geometric mean albumin excretion rates (AERs) were as follows: perindopril, 66 mug/min; nifedipine, 59 mug/min; and placebo, 66 mug/min. During the first 3 years, 7 of the perindopril-treated but none of the placebo or nifedipine-treated patients reverted to normoalbuminuria (P < 0.01). Median AERs at 3 years of treatment in each group were 23 g/min for perindopril, 122 mug/min for nifedipine, and 112 mug/min for placebo patients (P < 0.01). in patients with more than 3 years' follow-up, median AERs decreased by 45% in the first year and then stabilized in the perindopril group, but increased by 17.6% in the nifedipine group and 27.6% in the placebo group (P < 0.03) in the first year, then increased progressively. In these same patients, there was a significant decline in glomerular filtration rate in the nifedipine group (-7.8 +/- 1.8 mL/min/1.73 m(2)/y), but not in the other two groups (perindopril, -1.0 +/- 1.2 mL/min/1.73 m(2)/y; placebo, -1.3 +/- 1.1 mL/min/1.73 m(2)/y; P = 0.004). At the end or the study, cessation of treatment for 3 months was associated with a doubling of AERs in the perindopril-treated group, but no change in the other two groups (P < 0.001). In conclusion, long-term perindopril therapy is more effective than nifedipine or placebo in delaying the progression of diabetic nephropathy and reducing AER to the normoalbuminuric range (<20 mug/min) in normotensive patients with type I diabetes and microalbuminuria. (C) 2000 by the National Kidney Foundation, Inc.
• Huet,J., Bulletin de la Societe Chimique de France, 1964, p. 967 - 972
  作者：Huet,J.

  DOI：——

  日期：——