di-1-adamantyl hydrogen phosphite | 77075-16-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: di-1-adamantyl hydrogen phosphite
• 英文别名: di(1-adamantyl) H-phosphonate；di(adamant-1-yl) phosphite；diadamantyl H-phosphonate；di(1-adamantyl)phosphite；1-(1-Adamantyloxyphosphonoyloxy)adamantane
• CAS: 77075-16-2
• 化学式: C₂₀H₃₁O₃P
• 分子量: 350.438
• InChiKey: VIKKBPHCHTZWFE-UHFFFAOYSA-N

物化性质

• 沸点：
  455.0±12.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  di-1-adamantyl hydrogen phosphite 在 sulfur 作用下， 生成 O,O'-di(adamant-1-yl)-O-(4-nitrobenzyl)thiophosphate
  参考文献：
  名称：

  Di(adamant-1-yl)- and di(adamant-2-yl)thiophosphoric acids and their triethylammonium salts in alkylation reactions

  摘要：

  By reaction of di(adamant-1-yl) and di(adamant-2-yl) phosphites with sulfur in the presence of triethylamine diadamantylthiophosphoric acid triethylammonium salts were obtained. The latter by the action of hydrochloric acid were converted into free thiophosphoric acids and by the reaction of alkylation into the respective triesters which have thionic structure. Applicability in such reactions also of triethylammonium salts of diadamantyldithiophosphoric acids was demonstrated.

  DOI：

  10.1134/s1070363209080076
• 作为产物：
  描述：

  1-金刚烷醇 在 nickel on silica 、 次磷酸 作用下， 以 甲苯 为溶剂， 反应 20.0h， 生成 di-1-adamantyl hydrogen phosphite
  参考文献：
  名称：

  不含 PCl3 的有机磷化学：从次磷酸到 H-膦酸二酯的桥梁

  摘要：

  描述了将次磷酸 (H3PO2, HPA) 和醇转化为各种 H-膦酸二酯 [(RO)2P(O)H] 的过程。新反应在 HPA 和重要的 H-膦酸盐之间提供了一个缺失的桥梁，完全避免了 PCl3 的使用。氯化镍或二氧化硅上的镍催化烷基次膦酸盐与各种醇或水的氧化磷酸化。该反应是原子经济的，避免了废物的形成。完全避免了以前对氯和碱的需求。

  DOI：

  10.1002/ejoc.201301412

文献信息

• Lyase Enzymes, Nucleic Acids Encoding Them and Methods for Making and Using Them
  申请人：Weiner David

  公开号：US20110027346A1

  公开（公告）日：2011-02-03

  This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.

  这项发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在一个方面，该发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸裂解酶、酪氨酸裂解酶和/或组氨酸裂解酶活性，包括热稳定和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。该发明的多肽可用于各种制药、农业和工业领域。
• Lyaseenzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them
  申请人：Weiner David P.

  公开号：US20120177722A1

  公开（公告）日：2012-07-12

  This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and meth-°ds of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl.

  这项发明提供具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，该发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸裂解酶、酪氨酸裂解酶和/或组氨酸裂解酶活性，包括热稳定和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。该发明的多肽可以在各种制药、农业和工业环境中使用。X = NO2、Cl、Br、NH2、OH、H，在一个或多个o、m和p位置的烷基，R = H或烷基。
• Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them
  申请人：Weiner David P.

  公开号：US20090038023A1

  公开（公告）日：2009-02-05

  This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO 2 , Cl, Br, F, NH 2 , OH, H, alkyl at one or several o, m, and p positions R═H or alkyl

  本发明提供具有裂解酶活性的多肽，编码这些多肽的多核苷酸以及使用这些多核苷酸和多肽的制备和使用方法。在一个方面，本发明是针对具有氨裂解酶活性的多肽，例如苯丙氨酸裂解酶、酪氨酸裂解酶和/或组氨酸裂解酶活性，包括热稳定和热耐受性活性，以及编码这些酶的多核苷酸，制备和使用这些多核苷酸和多肽。本发明的多肽可用于各种制药、农业和工业背景中。其中，X═NO2、Cl、Br、F、NH2、OH、H，在一个或几个o、m和p位置上为烷基；R═H或烷基。
• Lyase enzymes, nucleic acids encoding them and methods for making and using them
  申请人：BASF Enzymes LLC

  公开号：EP2886658A1

  公开（公告）日：2015-06-24

  This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, eg phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.

  本发明提供了具有裂解酶活性的多肽、编码这些多肽的多核苷酸以及制造和使用这些多核苷酸和多肽的方法。在一个方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶、酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括恒温和耐热活性，以及编码这些酶的多核苷酸，以及制造和使用这些多核苷酸和多肽的方法。本发明的多肽可用于各种医药、农业和工业领域。
• Yurchenko, R. I.; Klepa, T. I.; Mishak, M. I., Journal of general chemistry of the USSR, 1980, vol. 50, # 11, p. 1972 - 1976
  作者：Yurchenko, R. I.、Klepa, T. I.、Mishak, M. I.、Tikhonov, V. P.

  DOI：——

  日期：——