2-氨基-7,9-二甲基-1，7,8,9-四氢-6H-嘌呤-6-酮 | 55235-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 2-氨基-7,9-二甲基-1，7,8,9-四氢-6H-嘌呤-6-酮
• 中文别名: 6H-嘌呤-6-酮，2-氨基-1，7,8,9-四氢-7,9-二甲基
• 英文名称: 7,9-Dimethyl-guanin
• 英文别名: 2-amino-7,9-dimethyl-1,7,8,9-tetrahydro-purin-6-one；2-Amino-7,9-dimethyl-7,8-dihydropurin-7-ium-6-olate；2-amino-7,9-dimethyl-7,8-dihydropurin-7-ium-6-olate
• CAS: 55235-22-8
• 化学式: C₇H₁₁N₅O
• 分子量: 181.197
• InChiKey: KKQKBURHSNOSCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  74
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Metal complexes of N-heterocyclic carbenes as radiopharmaceuticals and antibiotics
  申请人：Youngs Wiley

  公开号：US20070021401A1

  公开（公告）日：2007-01-25

  A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or more tissues of a patient includes administering an effective amount of a complex of a N-heterocyclic amine and a radioactive metal. A method for treating urinary tract infections utilizing silver complexes of N-heterocyclic carbenes. N-heterocyclic carbenes of the present invention may be represented by the formula wherein Z is a heterocyclic group, and R 1 and R 2 are, independently or in combination, hydrogen or a C 1 -C 12 organic group selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heterocyclic, and alkoxy groups and substituted derivatives thereof.

  一种抑制微生物生长的方法包括给予有效量的N-杂环胺的银络合物。一种治疗癌细胞或成像患者一个或多个组织的方法包括给予有效量的N-杂环胺和放射性金属的络合物。一种利用N-杂环卡宾银络合物治疗尿路感染的方法。本发明的N-杂环卡宾可以用以下式表示，其中Z是杂环基，而R1和R2是独立或组合的氢或选择自烷基、环烷基、烯基、环烯基、炔基、芳基、芳基烷基、烷基芳基、杂环和烷氧基和其取代衍生物的C1-C12有机基。
• Metal Complexes of N-Heterocyclic Carbenes as Radiopharmaceuticals and Antibiotics
  申请人：Youngs Wiley J.

  公开号：US20080267867A1

  公开（公告）日：2008-10-30

  A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or more tissues of a patient includes administering an effective amount of a complex of a N-heterocyclic amine and a radioactive metal. N-heterocyclic carbenes of the present invention may be represented by formula (I) wherein Z is a heterocyclic group, and R 1 and R 2 are, independently or in combination, hydrogen or a C 1 -C 12 organic group selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heterocyclic, and alkoxy groups and substituted derivatives thereof.

  一种抑制微生物生长的方法包括给予一种N-杂环胺的银络合物有效量。一种治疗癌细胞或成像患者的一个或多个组织的方法包括给予一种N-杂环胺和放射性金属的络合物有效量。本发明的N-杂环卡宾可以用式(I)表示，其中Z是一个杂环基团，R1和R2独立或组合地是氢或C1-C12有机基团，所述有机基团选自烷基，环烷基，烯基，环烯基，炔基，芳基，芳基烷基，烷基芳基，杂环和其取代衍生物。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• METAL COMPLEXES OF N-HETEROCYCLIC CARBENES AS RADIOPHARMACEUTICALS AND ANTIBIOTICS
  申请人：The University of Akron

  公开号：EP1660444A2

  公开（公告）日：2006-05-31
• EP1660444A4
  申请人：——

  公开号：EP1660444A4

  公开（公告）日：2007-12-26