(2S)-2,6-bis[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanamide | 1312667-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2S)-2,6-bis[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanamide
• CAS: 1312667-83-6
• 化学式: C₃₀H₃₇N₅O₅S₂
• 分子量: 611.786
• InChiKey: KMBVCNWFZKATCO-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  159
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  、 丹酰氯 在 哌啶 、 三乙胺 、 三异丙基硅烷 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 3.0h， 生成 (2S)-2,6-bis[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanamide
  参考文献：
  名称：

  Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells

  摘要：

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.106