dioctadecylammonium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dioctadecylammonium chloride
• 英文别名: dioctadecylammonium hydrochloride；distearyl ammonium chloride；Dioctadecylazanium;chloride
• 化学式: C₃₆H₇₅N*ClH
• 分子量: 558.459
• InChiKey: KGOGNDXXUVELIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.52
• 重原子数：
  38
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(2-氯羰基-乙基二磺酰基)-丙酰氯 、 dioctadecylammonium chloride 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以49%的产率得到N,N,N',N'-tetraoctadecyl-3,3'-(disulfanediyl)dipropanamide
  参考文献：
  名称：

  Lipopolycationic Telomers for Gene Transfer: Synthesis and Evaluation of Their in Vitro Transfection Efficiency

  摘要：

  We report on the synthesis of a series of lipopolyamine telomers I-14,n, I-18,n, and II-18,n and on their in vitro gene-transfer capability. Their structure consists of a polyamine polar moiety, including n primary amine functions (from 1 to 70), connected to a hydrophobic moiety, including two hydrocarbon C14 or C18 chains, through a mercaptopropanoyl or mercaptoglyceryl unit and an amide or ether function. They were obtained by telomerization of N-(2-[(BOC)aminoethyl]})acrylamide with N,N-ditetradecyl- and N,N-dioctadecylpropanamide-3-thiol and rac-1,2-dioctadecyloxypropane-3-thiol, respectively, then BOC deprotection. For NIP ratios (N = number of telomer amine equivalents; P = number of DNA phosphates) from 0.8 to 10, these lipopolyamines condensed DNA, with or without the use of DOPE, forming lipopolyplexes or teloplexes of mean sizes less than zoo nm. Some trends, structure-activity and structure-toxicity relationships, were established to achieve both highest in vitro transfection levels and cell viability. Thus, DNA formulations based on telomers I-14,20 and I-18,20 and for NIP ratios lower than 5 led to the most efficient teloplex formulations for plasmid delivery to lung epithelial A549 cells.

  DOI：

  10.1021/jm9911579
• 作为产物：
  描述：

  十八烷腈 生成 dioctadecylammonium chloride
  参考文献：
  名称：

  GALAN, AMALIA;DE, MENDOZA JAVIER;PRADOS, PILAR;ROJO, JAVIER;ECHAVARREN, A+, J. ORG. CHEM., 56,(1991) N, C. 452-454

  摘要：

  DOI：

文献信息

• Additives and products including oligoesters
  申请人：——

  公开号：US20030199593A1

  公开（公告）日：2003-10-23

  The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

  本发明涉及寡酯及其用途或添加剂的制备。含有寡酯的添加剂和/或寡酯本身可用于配制药物制剂、化妆品或个人护理产品，如洗发水和护发素。这些寡酯对于制备能够赋予调理、长效性和/或紫外线保护的多功能添加剂特别有用。描述了单独的寡酯和寡酯混合物。
• Imidazoline quats
  申请人：Croda, Inc.

  公开号：US20040220062A1

  公开（公告）日：2004-11-04

  Mixture of dialkyl imidazoline quats with specified substitution content are provided. In one embodiment, at least a portion of the mixture includes at least one dialkyl imidazoline quat having at least one C 16 -C 30 alkyl group; the C 16-30 substitution content of the mixture being from about 10% to about 95% with respect to C 10+ reference substitution range. Methods of making imidazoline quats and quat mixtures, personal care and cosmetic products and formulations that contain the imidazoline quats and quat mixtures, methods of making such personal care and cosmetic products and formulations, and methods of using the such imidazoline quats, quat mixtures, and personal care and cosmetic products and formulations are also provided. Various embodiments are disclosed.

  提供具有指定取代含量的二烷基咪唑啉季铵盐混合物。在一个实施例中，至少部分混合物包括至少一种具有至少一个C16-C30烷基基团的二烷基咪唑啉季铵盐；混合物的C16-C30取代含量相对于C10+参考取代范围约为10%至95%。还提供制备咪唑啉季铵盐和季铵盐混合物的方法，包含咪唑啉季铵盐和季铵盐混合物的个人护理和化妆品产品和配方，制备这种个人护理和化妆品产品和配方的方法，以及使用这种咪唑啉季铵盐、季铵盐混合物、个人护理和化妆品产品和配方的方法。还披露了各种实施例。
• Polyamine compounds and compositions containing them useful for the transfer of active substances into a cell
  申请人：TRANSGENE S.A.

  公开号：EP0965583A1

  公开（公告）日：1999-12-22

  The application relates to polyamine telomer compounds comprising the group of the formula I wherein: A is H or an alkyl of 1 to 4 carbon atoms or an aryl of 5 to 7 carbon atoms, the degree of polymerization n ranges from 1 to 100, R1 is selected, independently of one another in each [CH2-CA] n repeat, from -H, -CH3, -C2H5 and - (CH2)u-B, x and u are integers from 2 to 4, B being wherein: y is an integer from 2 to 4, z is an integer from 0 to 6, R3, R4, R5, R6 and R7 are selected, independently of one another, from H, alkyl or hydroxyalkyl of 1 to 4 carbon atoms.

  该申请涉及聚胺基寡聚物化合物，其包括以下式I的基团：其中：A为H或1至4个碳原子的烷基或5至7个碳原子的芳基，聚合度n范围为1至100，R1在每个[CH2-CA] n重复中独立选择为-H、-CH3、-C2H5和-(CH2)u-B，x和u为2至4的整数，B为其中：y为2至4的整数，z为0至6的整数，R3、R4、R5、R6和R7在彼此独立选择为H、1至4个碳原子的烷基或羟基烷基。
• イオン性化合物、有機エレクトロニクス材料、有機エレクトロニクス素子、及び有機エレクトロルミネセンス素子
  申请人：日立化成株式会社

  公开号：JP2017218426A

  公开（公告）日：2017-12-14

  【課題】インク組成物に用いたときに、インク組成物としての保存安定性を向上させることができるイオン性化合物及び有機エレクトロニクス材料を提供する。【解決手段】下記式（１ａ）で表されるアンモニウムカチオンとアニオンとからなるイオン性化合物。式（１ａ）中、Ｒ１およびＲ２はそれぞれ独立に１価の有機基を表す。【選択図】なし

  提供可以提高墨水组成物作为墨水组成物的保存稳定性的离子化合物和有机电子材料。根据以下式（1a）表示的由氨基阳离子和阴离子组成的离子化合物。在式（1a）中，R1和R2分别独立表示1价有机基。【选择图】无
• Compositions containing esters of aromatic alkoxylated alcohols and fatty carboxylic acids
  申请人：——

  公开号：US20030161792A1

  公开（公告）日：2003-08-28

  A personal care or cosmetic product composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional ingredients in the composition may include active ingredients and additional ingredients. Especially suitable active ingredients are sunscreen active ingredients and antiperspirant active ingredients. Preferred compositions are sunscreen product formulations and antiperspirant products. In one preferred embodiment, the composition further includes at least one cyclomethicone compound present in the amount of from about 1% to 99% by weight of the composition. A method of improving the protection of human or animal skin or hair from radiation and a method of improving the protection of human or animal skin or hair from perspiration are also provided.

  提供一种个人护理或化妆品组合物，包括约0.1%至约99%的至少一种烷氧基芳香醇和脂肪羧酸酯，以及约0.1%至60%的至少一种功能性成分。组合物中的功能性成分可能包括活性成分和额外成分。特别适用的活性成分包括防晒活性成分和止汗活性成分。首选的组合物是防晒产品配方和止汗产品。在一个首选实施例中，该组合物还包括至少一种环硅烷化合物，其占组合物重量的约1%至99%。还提供了一种改善人类或动物皮肤或毛发免受辐射的保护的方法，以及一种改善人类或动物皮肤或毛发免受汗水侵害的方法。

表征谱图