7-dimethylallyloxy-5-hydroxy-3-methylchromone | 1131007-64-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-dimethylallyloxy-5-hydroxy-3-methylchromone
• 英文别名: 5-Hydroxy-3-methyl-7-(3-methylbut-2-enoxy)chromen-4-one
• CAS: 1131007-64-1
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: QUFCGVITIIOBDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,7-Dihydroxy-3-methylchromone 、 1-溴-3-甲基-2-丁烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以65%的产率得到7-dimethylallyloxy-5-hydroxy-3-methylchromone
  参考文献：
  名称：

  Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities

  摘要：

  Chromone glucosides, takanechromones A-C (1, 2 and S) and chromanone glucosides, named takanechromanones A and B (3 and 4), were isolated from the methanolic extracts of Hypericum sikokumontanum together with 27 known compounds. Their structures were established based on spectroscopic evidence. The isolated compounds and some chromone derivatives were assayed for antimicrobial activity against Helicobacter pylori and cytotoxicity against human cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2008.11.006

文献信息

• Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities
  作者：Naonobu Tanaka、Yoshiki Kashiwada、Tatsuro Nakano、Hirofumi Shibata、Tomihiko Higuchi、Michiko Sekiya、Yasumasa Ikeshiro、Yoshihisa Takaishi

  DOI：10.1016/j.phytochem.2008.11.006

  日期：2009.1

  Chromone glucosides, takanechromones A-C (1, 2 and S) and chromanone glucosides, named takanechromanones A and B (3 and 4), were isolated from the methanolic extracts of Hypericum sikokumontanum together with 27 known compounds. Their structures were established based on spectroscopic evidence. The isolated compounds and some chromone derivatives were assayed for antimicrobial activity against Helicobacter pylori and cytotoxicity against human cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.