ethyl 4H-chromene-3-carboxylate | 120450-85-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: ethyl 4H-chromene-3-carboxylate
• CAS: 120450-85-3
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: OPPMDBOTESKTIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl (E)-3-morpholinoacrylate 、 水杨醇 在 乙酸酐 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以12%的产率得到ethyl 4H-chromene-3-carboxylate
  参考文献：
  名称：

  Loic, Rene, Synthesis, 1989, # 1, p. 69 - 70

  摘要：

  DOI：

文献信息

• RENE, LOIC, SYNTHESIS,(1989) C. 69-70
  作者：RENE, LOIC

  DOI：——

  日期：——
• CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS
  申请人：Deutsches Krebsforschungszentrum (DKFZ)

  公开号：EP2638025A2

  公开（公告）日：2013-09-18
• [EN] BENZOPYRANES USEFUL AS TNF ALPHA INHIBITORS<br/>[FR] BENZOPYRANES UTILES COMME INHIBITEURS DE TNF-ALPHA
  申请人：CHUGAI PHARMACEUTICAL CO LTD

  公开号：WO2001072735A2

  公开（公告）日：2001-10-04

  This invention relates to novel compounds of formula (I) capable of inhibiting TNF alpha and having antiinflammatory properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
• [EN] CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS<br/>[FR] DÉRIVÉS DE CHROMÈNE ET LEURS ANALOGUES À TITRE D'ANTAGONISTES DE LA VOIE WNT
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2012062901A2

  公开（公告）日：2012-05-18

  Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
• [EN] CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS<br/>[FR] DÉRIVÉS DE CHROMÈNE ET LEURS ANALOGUES EN TANT QU'ANTAGONISTES DE LA VOIE WNT
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2012062905A2

  公开（公告）日：2012-05-18

  Compounds according to the general formula (I) wherein X1, X2, X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different, and wherein up to 3 of the group X1, X2, X3 and X4 may be N; A is a 5- or 6-membered aromatic or heteroaromtic cycle containing 1 to 3 heteroatoms selected from the group consisting of N, O and S wherein A may be substituted by 1 to 5 substituents R which may be same or different; their solvates, hydrates, and pharmaceutically acceptable salts for the treatment of a disorder or disease associated with an aberrant activation of Wnt signalling in a mammal selected from a cell proliferative disorder, rheumatoid arthritis, increased bone density, aging or age-related disorders and/or diseases or Dupuytren disease (superficial fibromatosis).