2-pivaloylaminopyrimidine | 544415-03-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-pivaloylaminopyrimidine
• 英文别名: 2,2-dimethyl-N-pyrimidin-2-ylpropanamide
• CAS: 544415-03-4
• 化学式: C₉H₁₃N₃O
• mdl: MFCD00838285
• 分子量: 179.222
• InChiKey: FDSDCQFFMLXXFA-UHFFFAOYSA-N

物化性质

• 密度：
  1.130±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯嘧啶 、 三甲基乙酰胺 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以96%的产率得到2-pivaloylaminopyrimidine
  参考文献：
  名称：

  Palladium-catalyzed amidation of 2-chloropyrimidines

  摘要：

  A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.12.088

文献信息

• PYRAZOLE AMIDE COMPOUNDS AND USES THEREOF
  申请人：Liu Changling

  公开号：US20130225585A1

  公开（公告）日：2013-08-29

  Disclosed is a pyrazole amide compound having fungicidal activity, with a structure shown by the general formula (I): Each of the substituents of the compound being defined as in the description. The compound of the present invention has fungicidal activity, and excellent prevention and controlling effects on diseases, such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, etc., and in particular, a better prevention and controlling effect on cucumber downy mildew and corn rust. Also disclosed is a process for preparing the compound, a fungicidal composition containing the compound of general formula (I) and the use thereof in preventing and controlling disease in crops.

  本发明揭示了一种具有杀真菌活性的吡唑酰胺化合物，其结构由通式（I）所示：化合物的每个取代基均如描述中所定义。本发明的化合物具有杀真菌活性，并对瓜类霜霉病、玉米锈病、小麦白粉病、水稻稻瘟等疾病具有优异的预防和控制效果，尤其对瓜类霜霉病和玉米锈病有更好的预防和控制效果。还公开了一种制备该化合物的方法，含有通式（I）化合物的杀真菌组合物以及其在农作物疾病预防和控制中的应用。
• Synthesis and antibiofilm evaluation of N-acyl-2-aminopyrimidine derivatives against Acinetobacter baumannii
  作者：Xue-Min Jia、Cheng Cheng、Ting Liu、Yong-Long Zhao、Bing Guo、Lei Tang、Yuan-Yong Yang

  DOI：10.1016/j.bmc.2022.117095

  日期：2022.12
• METHODS OF USING EHMT2 INHIBITORS
  申请人：Epizyme, Inc.

  公开号：US20200113901A1

  公开（公告）日：2020-04-16

  The present disclosure relates to a method of preventing or treating an imprinting disorder via administering an EHMT2 inhibitor compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
• AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20200317642A1

  公开（公告）日：2020-10-08

  The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
• Palladium-catalyzed amidation of 2-chloropyrimidines
  作者：Marc Vimolratana、Jillian L. Simard、Sean P. Brown

  DOI：10.1016/j.tetlet.2010.12.088

  日期：2011.3

  A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1. (C) 2010 Elsevier Ltd. All rights reserved.