N-n-butyl-N-(2-diethylaminoethyl)amine | 50342-04-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-n-butyl-N-(2-diethylaminoethyl)amine
• 英文别名: N'-butyl-N,N-diethyl-ethane-1,2-diamine；N,N-diethyl-N'-butyl-ethylenediamine；N,N-Diaethyl-N'-butyl-aethylendiamin；N-butyl-N',N'-diethylethane-1,2-diamine
• CAS: 50342-04-6
• 化学式: C₁₀H₂₄N₂
• mdl: MFCD11144302
• 分子量: 172.314
• InChiKey: LQVFVMJVCVOTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-溴甲基喹啉 、 N-n-butyl-N-(2-diethylaminoethyl)amine 在 potassium carbonate 、 苯 作用下， 生成 N,N-diethyl-N'-butyl-N'-[8]quinolylmethyl-ethylenediamine
  参考文献：
  名称：

  Kermack; Wight, Journal of the Chemical Society, 1935, p. 1425

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙氨基乙醇 在 氯化亚砜 、 水 、 苯 作用下， 生成 N-n-butyl-N-(2-diethylaminoethyl)amine
  参考文献：
  名称：

  Pecher; Martin, Bulletin des Societes Chimiques Belges, 1957, vol. 66, p. 545,561

  摘要：

  DOI：

文献信息

• Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.
  作者：Seigo SAWADA、Satoru OKAJIMA、Ritsuo AIYAMA、Ken-ichiro NOKATA、Tomio FURUTA、Teruo YOKOKURA、Eiichi SUGINO、Kentaro YAMAGUCHI、Tadashi MIYASAKA

  DOI：10.1248/cpb.39.1446

  日期：——

  Nevel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HC1 salts wiht the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors.The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.

  Nevel 36衍生物（6个）通过单氨基甲酸酯连接，将7-乙基-10-羟基喜树碱（4）的酚羟基与二胺结合，经过合成并在体内评估了它们的抗肿瘤活性。这些衍生物作为盐酸盐在水中有较好的溶解度，且其E内酯环保持完整，并表现出显著的抗肿瘤活性。其中一种衍生物6-27对L1210白血病和其他小鼠肿瘤显示出极佳的活性。其三水合盐酸盐（CPT-11）的结构通过光谱学和结晶学方法得以确定。
• LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE
  申请人：Ortega Muñoz Alberto

  公开号：US20120283266A1

  公开（公告）日：2012-11-08

  The invention relates to a compound of Formula (I): (A′) x -(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A′), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; (L) is chosen from —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, and —CH 2 CH 2 CH 2 CH 2 —; and (D) is chosen from —N(—R1)—R2, —O—R3, and —S—R3, wherein: R1 and R2 are mutually linked to form a heterocyclic ring together with the nitrogen atom that R1 and R2 are attached to, wherein said heterocyclic ring has 0, 1, 2, or 3 substituents independently chosen from —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and haloalkoxy, or R1 and R2 are independently chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein the sum of substituents on R1 and R2 together is 0, 1, 2, or 3, and the substituents are independently chosen from —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), and fluoro; and R3 is chosen from —H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl, wherein R3 has 0, 1, 2, or 3 substituents independently chosen from —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), and fluoro; or an enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt or solvate thereof. The compounds of the invention show inhibitory LSD1 activity, which makes them useful in the treatment or prevention of diseases such as cancer.

  本发明涉及一种化合物，其化学式为(I):(A′)x-(A)-(B)-(Z)-(L)-(D)，其中：(A)为杂环芳基或芳基；每个(A′)，如果存在，则独立选择自芳基、芳基烷氧基、芳基烷基、杂环芳基、芳基氧基、卤、烷氧基、卤代烷基、环烷基、卤代烷氧基和氰，其中每个(A′)均被取代为0、1、2或3个取代基，所述取代基独立选择自卤、卤代烷基、芳基、芳基烷氧基、烷基、烷氧基、氰、磺酰基、酰胺和亚磺酰基；X为0、1、2或3；(B)为环丙基环，其中(A)和(Z)与(B)的不同碳原子共价键合；(Z)为—NH—；(L)选择自—CH2CH2—、—CH2CH2CH2—和—CH2CH2CH2CH2—；(D)选择自—N(—R1)—R2、—O—R3和—S—R3，其中：R1和R2与氮原子一起互相连接形成一个杂环环，所述杂环环具有0、1、2或3个取代基，所述取代基独立选择自—NH2、—NH(C1-C6烷基)、—N(C1-C6烷基)(C1-C6烷基)、烷基、卤、氰、烷氧基、卤代烷基和卤代烷氧基，或R1和R2独立选择自—H、烷基、环烷基、卤代烷基和杂环芳基，其中R1和R2的取代基总和为0、1、2或3，所述取代基独立选择自—NH2、—NH(C1-C6烷基)、—N(C1-C6烷基)(C1-C6烷基)和氟；R3选择自—H、烷基、环烷基、卤代烷基和杂环芳基，其中R3具有0、1、2或3个取代基，所述取代基独立选择自—NH2、—NH(C1-C6烷基)、—N(C1-C6烷基)(C1-C6烷基)和氟；或其对映体、顺反异构体或混合物，或其药学上可接受的盐或溶剂。本发明的化合物显示出抑制LSD1活性，因此它们在治疗或预防癌症等疾病方面非常有用。
• Chlorine-resistant polyethylene compound and articles made therefrom
  申请人：Fina Technology, Inc.

  公开号：US10584823B2

  公开（公告）日：2020-03-10

  A method includes transporting water containing chlorine dioxide, chlorine, chloramines, or hypochlorites through a pipe. The method includes forming a polyethylene resin using a catalyst, mixing the polyethylene resin with an antioxidant, wherein the antioxidant is a thioester, a hindered amine light stabilizer or 1,3,5-trimethyl-2,4,6-tris (3,5-di-tert-butyl-4-hydroxybenzyl) benzene to form a resin/antioxidant mixture, extruding pipe from the resin/antioxidant mixture, and flowing water containing chlorine dioxide, chlorine, chloramines, or hypochlorites through the pipe. An extruded article is adapted for use in containment and/or transport of water that contains chlorine dioxide, chlorine, chloramines, or hypochlorites. The extruded article includes a polyethylene resin and an antioxidant. The antioxidant is a thioester, a hindered amine light stabilizer or 1,3,5-trimethyl-2,4,6-tris (3,5-di-tert-butyl-4-hydroxybenzyl) benzene.

  一种方法包括通过管道输送含有二氧化氯、氯、氯胺或次氯酸盐的水。该方法包括使用催化剂形成聚乙烯树脂，将聚乙烯树脂与抗氧化剂混合，其中抗氧化剂为硫酯、受阻胺光稳定剂或 1，3，5-三甲基-2，4，6-三（3、5-二叔丁基-4-羟基苄基）苯形成树脂/抗氧化剂混合物，用树脂/抗氧化剂混合物挤出管材，并使含有二氧化氯、氯、氯胺或次氯酸盐的水流过管材。挤压制品适用于封闭和/或运输含有二氧化氯、氯、氯胺或次氯酸盐的水。挤压制品包括聚乙烯树脂和抗氧化剂。抗氧化剂是硫酯、受阻胺光稳定剂或 1,3,5-三甲基-2,4,6-三（3,5-二叔丁基-4-羟基苄基）苯。
• Wadia et al., Journal Of Scientific and Industrial Research, 1958, vol. 17B, p. 11,20
  作者：Wadia et al.

  DOI：——

  日期：——
• Thuillier,G. et al., Bulletin de la Societe Chimique de France, 1963, p. 1087 - 1090
  作者：Thuillier,G. et al.

  DOI：——

  日期：——