1-(4-methylnaphthalen-1-yl)piperidine | 507476-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-methylnaphthalen-1-yl)piperidine
• 英文别名: 1-(4-Methyl-1-naphthalenyl)piperidine
• CAS: 507476-71-3
• 化学式: C₁₆H₁₉N
• 分子量: 225.334
• InChiKey: RVCQHSKOCZQSIA-UHFFFAOYSA-N

物化性质

• 熔点：
  57-57.8 °C
• 沸点：
  193.5-196 °C(Press: 12 Torr)
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二甲基-1-(萘-1-基)甲胺 在 palladium diacetate 、 三苯基膦 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 5.25h， 生成 1-(4-methylnaphthalen-1-yl)piperidine
  参考文献：
  名称：

  钯催化苯胺铵盐与胺的高度区域选择性芳香取代。

  摘要：

  通过钯催化的CN键裂解，已经开发出前所未有的苄基铵盐的芳族取代反应。一系列伯胺和仲胺参与了钯催化的苄基铵盐的芳族取代反应，以中等至极好的收率提供了位阻芳族胺，且具有极高的区域选择性。初步的机理研究成功地鉴定出π-苄基钯配合物和γ-乙烯基烯丙基胺为关键中间体。该研究为在芳族取代反应中使用苄基铵盐铺平了道路。

  DOI：

  10.1021/acs.orglett.9b02820

文献信息

• ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS
  申请人：Boehringer Ingelheim Animal Health USA Inc.

  公开号：EP3922639A1

  公开（公告）日：2021-12-15

  The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

  本发明提供了对危害动物的寄生虫有效的式(I)环状去肽化合物和包含该化合物的组合物。这些化合物和组合物可用于防治哺乳动物和鸟类体内或身上的寄生虫。本发明还提供了一种根除、控制和预防鸟类和哺乳动物体内寄生虫侵扰的改进方法。
• Sauer et al., Chemische Berichte, 1958, vol. 91, p. 1461,1472
  作者：Sauer et al.

  DOI：——

  日期：——
• Palladium-Catalyzed Amination of Chloromethylnaphthalene and Chloromethylanthracene Derivatives with Various Amines
  作者：Sheng Zhang、Yi Wang、Xiujuan Feng、Ming Bao

  DOI：10.1021/ja300164d

  日期：2012.3.28

  Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives to produce naphthylamines and anthrylamines in satisfactory to good yields has been developed. The unprecedented amination reactions proceeded smoothly under mild conditions in the presence of Pd(PPh3)(4) as a catalyst.
• Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines
  作者：Tammy Wang、David R. Magnin、Lawrence G. Hamann

  DOI：10.1021/ol034072h

  日期：2003.3.1

  1-Aminonaphthalenes and 5- and 8-aminoquinolines were rapidly prepared from the respective aryl bromides in good yields by Pd-catalyzed aryl amination under microwave conditions. Consistent improvements in yields over those obtained under standard conditions were seen with quinoline substrates. In the cases where 5-bromo-8-cyanoquinoline was used as a substrate, no desired products were obtained under standard conditions with a number of different primary and secondary amines. However, microwave conditions provided the desired products in good to excellent yields.
• Huisgen; Sauer, Angewandte Chemie, 1957, vol. 69, p. 390
  作者：Huisgen、Sauer

  DOI：——

  日期：——