6-Ethyl-5-methyl-2H-1,2lambda~6~,3-oxathiazine-2,2,4(3H)-trione | 33665-98-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 6-Ethyl-5-methyl-2H-1,2lambda~6~,3-oxathiazine-2,2,4(3H)-trione
• 英文别名: 6-ethyl-5-methyl-2,2-dioxooxathiazin-4-one
• CAS: 33665-98-4
• 化学式: C₆H₉NO₄S
• 分子量: 191.21
• InChiKey: CQOUMHHIZQPSBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Antimicrobial Devices and Compositions
  申请人：Karandikar Bhalchandra M.

  公开号：US20090035342A1

  公开（公告）日：2009-02-05

  The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.

  本发明涉及一种包括金属含量组合物的抗菌装置的方法和组合物，该组合物对热和光变色具有抗性。金属含量组合物可以包括银、铜或锌的盐或络合物。在一方面，组合物包括银盐。在另一方面，组合物包括银络合物。在一方面，金属盐可以包括糖精盐、乙酰糖胺盐、长链脂肪酸盐和烷基二羧酸盐。该组合物进一步包括与银、铜或锌形成盐或络合物的聚合物。本发明的方法包括使用金属含量组合物处理装置，包括但不限于编织伤口护理材料、导管、患者护理设备和胶原蛋白基质等装置。本发明还包括使用上述抗菌装置治疗人类和动物的方法。
• METHOD FOR PRODUCING 3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE COMPOUND OR SALT THEREOF
  申请人：Saito Akira

  公开号：US20090318685A1

  公开（公告）日：2009-12-24

  A high quality 3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide compound or a salt thereof is obtained easily and efficiently. When the compound represented by the following formula (2) (wherein, R 1 , R 2 , and R 3 are hydrogen atom or an organic group inert to the reaction, and X is hydrogen atom) or a salt thereof is produced by cyclization of a mixture of β-ketoamide-N-sulfonic acid represented by the following formula (1) or a salt thereof and an inert solvent and a mixture of acid anhydride and an inert solvent, and by subsequent hydrolysis of the product, a step of (A) hydrolyzing the reaction product obtained by the cyclization by mixing with an aqueous solution of sulfuric acid so as a concentration of sulfuric acid in an aqueous phase after the hydrolysis would become 30% by weight or more, and then separating an organic phase and an aqueous phase, or a step of (B) washing the organic phase liquid after the hydrolysis with an aqueous solution of sulfuric acid with a concentration of 30% by weight or more is at least carried out.

  可以轻松高效地获得高质量的3,4-二氢-1,2,3-噁嗪-4-酮-2,2-二氧化物化合物或其盐。当通过以下公式（1）所代表的β-酮酰胺-N-磺酸或其盐和惰性溶剂的混合物以及酸酐和惰性溶剂的混合物经环化反应得到以下公式（2）所代表的化合物（其中，R1、R2和R3是氢原子或对反应惰性的有机基团，X是氢原子），并通过随后的水解反应，至少进行以下步骤之一：（A）通过将环化反应所得反应产物与硫酸水溶液混合使得水解后的水相中硫酸的浓度达到30%或更高，然后分离有机相和水相；（B）用30%或更高浓度的硫酸水溶液洗涤水解后的有机相液体。
• Method for producing 3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide compound or salt thereof
  申请人：Kobayashi Kenji

  公开号：US20050182255A1

  公开（公告）日：2005-08-18

  A method produces a 3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide compound of following formula (2): wherein R 1 and R 2 are the same as or different from each other and are each hydrogen atom or an organic group inert to the reaction; and R 3 is hydrogen atom or an organic group inert to the reaction, or a salt thereof, by subjecting a beta-ketoamide-N-sulfonic acid of following Formula (1): wherein R 1 , R 2 and R 3 are as defined above; and X is hydrogen atom, or a salt thereof, to cyclization in the presence of an acid anhydride with or without further subjecting the cyclized product to hydrolysis, in which the cyclization is continuously carried out using a continuous flow reactor.

  一种方法通过在连续流反应器中将以下式子（1）中的β-酮酰胺-N-磺酸与酸酐在存在或不存在水解的情况下环化，制备出下式（2）的3,4-二氢-1,2,3-噁嗪-4-酮-2,2-二氧化物化合物：其中R1和R2相同或不同，均为氢原子或对反应不活泼的有机基团；R3为氢原子或对反应不活泼的有机基团或其盐。其中，X为氢原子或其盐。
• Methods and compositions for metal nanoparticle treated surfaces
  申请人：Avent, Inc.

  公开号：EP2859961A2

  公开（公告）日：2015-04-15

  Disclosed is method of making metal nanoparticles comprising, a) adding in no particular order, an aqueous solution of a stabilizing agent solution, an anionic donating solution and a soluble metal salt solution, and b) adding a reducing solution. Also disclosed are metal nanoparticles made by the method.

  所公开的金属纳米粒子的制造方法包括 a) 不按特定顺序加入稳定剂溶液、阴离子捐献溶液和可溶性金属盐溶液的水溶液，以及 b) 加入还原溶液。 还公开了用该方法制得的金属纳米粒子。
• Antimicrobial devices and compositions
  申请人：Karandikar Bhalchandra M.

  公开号：US10251392B2

  公开（公告）日：2019-04-09

  The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.

  本发明包括用于抗菌装置的方法和组合物，其中包含耐热和耐光变色的含金属组合物。含金属的组合物可包括银、铜或锌的盐或络合物。一方面，组合物包含银盐。另一方面，组合物还包括银络合物。一方面，金属盐可包括糖精、安赛蜜、长链脂肪酸和烷基二羧酸的金属盐。组合物还包括与银、铜或锌形成盐或络合物的聚合物。本发明的方法包括用含金属的组合物处理设备，包括但不限于编织伤口护理材料、导管、病人护理设备和胶原蛋白基质等设备。本发明还包括用本文所述的抗菌装置处理人和动物。