甘氨石胆酸乙酯 | 100929-89-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 甘氨石胆酸乙酯
• 英文名称: Glycolithocholic acid ethyl ester
• 英文别名: ethyl 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetate
• CAS: 100929-89-3
• 化学式: C₂₈H₄₇NO₄
• 分子量: 461.7
• InChiKey: JRXQPFBKHYDFPV-CUYCEIPOSA-N

物化性质

• 沸点：
  587.0±20.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  glycocholic acid 、 Sodium glycocholate hydrate, 98% 、 Glycodeoxycholic acid monohydrate 、 sodium;(4R)-N-(carboxymethyl)-4-[(3R,10S,12S,13R,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanimidate 、 、 甘氨石胆酸乙酯 生成 glycochenodeoxycholic acid sodium salt
  参考文献：
  名称：

  Compositions and methods for analyzing biomolecules using mass spectroscopy

  摘要：

  本发明揭示了用于质谱分析的组合物和方法。所述组合物和方法涉及使用质谱分析分析蛋白质和其他生物高分子，尤其是基质辅助激光解吸飞行时间质谱（MALDI-TOF MS）。

  公开号：

  US20060214104A1

文献信息

• Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
  申请人：Kudlicki Antoni Wieslaw

  公开号：US20060110788A1

  公开（公告）日：2006-05-25

  Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

  本文提供了用于合成生物分子（如多肽）的体外系统的组合物、方法和试剂盒。还提供了使用体外蛋白质合成方法提供增强可溶蛋白质收率的细胞提取物。本发明还包括通过向正在进行的体外合成系统添加包括氨基酸和能量来源的喂养溶液来产生高产量蛋白质的方法。本发明还包括使用高产量体外合成系统来生产大量含有标记氨基酸的蛋白质，以便通过NMR等方法进行分析的方法。本发明还包括用于增强从核酸模板中产生蛋白质的体外合成系统的载体。
• Compositions and Methods for Analyzing Biomolecules Using Mass Spectroscopy
  申请人：Pope Robert Marshall

  公开号：US20100187475A1

  公开（公告）日：2010-07-29

  Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).

  本发明涉及质谱分析的组合物和方法。这些组合物和方法涉及使用质谱分析技术对蛋白质和其他生物高分子进行分析，特别是基质辅助激光解吸飞行时间质谱（MALDI-TOF MS）技术。
• FEEDING BUFFERS, SYSTEMS, AND METHODS FOR IN VITRO SYNTHESIS OF BIOMOLECULES
  申请人：KUDLICKI Wieslaw Antoni

  公开号：US20120190064A1

  公开（公告）日：2012-07-26

  Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

  本文提供了用于生物分子合成的体外系统的组合物、方法和试剂盒，例如多肽。提供了使用体外蛋白质合成方法提供增强溶解蛋白质产量的细胞提取物。该发明还包括通过向正在进行的体外合成系统添加包括氨基酸和能量源的饲料溶液来产生高产量蛋白质的方法。该发明还包括使用高产量体外合成系统来生产大量具有标记氨基酸的蛋白质，以便通过NMR等方法进行分析的方法。该发明还包括用于使用体外合成系统从核酸模板增强蛋白质生产的载体。
• Compositions and methods for analyzing biomolecules using mass spectroscopy
  申请人：Pope Marshall Robert

  公开号：US20060214104A1

  公开（公告）日：2006-09-28

  Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).

  本发明揭示了用于质谱分析的组合物和方法。所述组合物和方法涉及使用质谱分析分析蛋白质和其他生物高分子，尤其是基质辅助激光解吸飞行时间质谱（MALDI-TOF MS）。