6-(bis(ethylthio)methyl)-2-dimethylaminonaphthalene | 1375090-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(bis(ethylthio)methyl)-2-dimethylaminonaphthalene
• 英文别名: 6-[bis(ethylsulfanyl)methyl]-N,N-dimethylnaphthalen-2-amine
• CAS: 1375090-65-5
• 化学式: C₁₇H₂₃NS₂
• 分子量: 305.508
• InChiKey: MWDJFRHYXCFOPF-UHFFFAOYSA-N

物化性质

• 沸点：
  448.5±35.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  53.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(bis(ethylthio)methyl)-2-dimethylaminonaphthalene 在 水 、 mercury dichloride 作用下， 生成 6-(二甲基氨基)-2-萘醛
  参考文献：
  名称：

  Reaction-Based Two-Photon Probes for Mercury Ions: Fluorescence Imaging with Dual Optical Windows

  摘要：

  For fluorescent imaging of mercury ions in living species, two-photon probes with dual optical windows are in high demand but remain unexplored. Several dithioacetals were evaluated, and a probe was found, which, upon reaction with mercury species, yielded a two-photon dye; this conversion accompanies ratiometric emission changes with a 97-nm shift, enabling fluorescent imaging of both the probe and mercury ions in cells by one- and two-photon microscopy for the first time.

  DOI：

  10.1021/ol3009057
• 作为产物：
  描述：

  6-(二甲基氨基)-2-萘醛 、 乙硫醇 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到6-(bis(ethylthio)methyl)-2-dimethylaminonaphthalene
  参考文献：
  名称：

  Reaction-Based Two-Photon Probes for Mercury Ions: Fluorescence Imaging with Dual Optical Windows

  摘要：

  For fluorescent imaging of mercury ions in living species, two-photon probes with dual optical windows are in high demand but remain unexplored. Several dithioacetals were evaluated, and a probe was found, which, upon reaction with mercury species, yielded a two-photon dye; this conversion accompanies ratiometric emission changes with a 97-nm shift, enabling fluorescent imaging of both the probe and mercury ions in cells by one- and two-photon microscopy for the first time.

  DOI：

  10.1021/ol3009057

文献信息

• Reaction-Based Two-Photon Probes for Mercury Ions: Fluorescence Imaging with Dual Optical Windows
  作者：Alla Sreenivasa Rao、Dokyoung Kim、Taejun Wang、Ki Hean Kim、Sekyu Hwang、Kyo Han Ahn

  DOI：10.1021/ol3009057

  日期：2012.5.18

  For fluorescent imaging of mercury ions in living species, two-photon probes with dual optical windows are in high demand but remain unexplored. Several dithioacetals were evaluated, and a probe was found, which, upon reaction with mercury species, yielded a two-photon dye; this conversion accompanies ratiometric emission changes with a 97-nm shift, enabling fluorescent imaging of both the probe and mercury ions in cells by one- and two-photon microscopy for the first time.