N-(pentan-5-ol)-4-chloro-1,8-naphthalimide | 330649-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(pentan-5-ol)-4-chloro-1,8-naphthalimide
• 英文别名: N-(5'-Hydroxypentyl)-4-chloronaphthalene-1,8-dicarboximide；N-(5-pentanol)-4-chloro-1,8-naphthalimide；6-Chloro-2-(5-hydroxypentyl)benzo[de]isoquinoline-1,3-dione
• CAS: 330649-49-5
• 化学式: C₁₇H₁₆ClNO₃
• 分子量: 317.772
• InChiKey: QOBZTABROKPLAX-UHFFFAOYSA-N

物化性质

• 沸点：
  521.6±35.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(pentan-5-ol)-4-chloro-1,8-naphthalimide 在 三溴化磷 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 以74%的产率得到
  参考文献：
  名称：

  Naphthalimide based novel organoselenocyanates: Finding less toxic forms of selenium that would retain protective efficacy

  摘要：

  A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.127
• 作为产物：
  描述：

  5-氨基-1-戊醇 、 4-氯-1,8-萘二甲酸酐 以 甲苯 为溶剂， 反应 16.0h， 以91.7%的产率得到N-(pentan-5-ol)-4-chloro-1,8-naphthalimide
  参考文献：
  名称：

  Composition Comprising a Monomer Compound Exhibiting an Optical Property, Method Making Use of Said Composition, a Monomer Compound and a Polymer Containing Said Monomer Compound and the Use Thereof

  摘要：

  该发明涉及一种化妆品或药用组合物，包括在生理上可接受的介质中，至少一种含有至少一种表现出光学特性的新型单体化合物的聚合物。该发明还涉及一种化妆方法，用于化妆或处理角质材料，特别是身体或面部皮肤、嘴唇、指甲、眉毛、睫毛和/或头发，包括将该化妆品组合物应用于所述材料。还公开了表现出光学特性的新型单体化合物、含有该化合物的聚合物以及将其用于组合物中以转移光学特性，特别是荧光或光亮剂特性。

  公开号：

  US20080226581A1

文献信息

• Composition Comprising a Monomer Compound Exhibiting an Optical Property, Method Making Use of Said Composition, a Monomer Compound and a Polymer Containing Said Monomer Compound and the Use Thereof
  申请人：Luukas Timo

  公开号：US20080226581A1

  公开（公告）日：2008-09-18

  The invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one type of polymer containing at least one type of novel monomer compound exhibiting optical properties. Said invention also relates to a cosmetic method for making up or treating keratinous materials, in particular a body or face skin, lips, nails, eyebrows, eyelashes and/or hairs, including the application of said cosmetic composition to said materials. Novel monomer compounds exhibiting optical properties, polymers containing said compounds and the use thereof in a composition in order to transfer the optical properties thereto, in particular fluorescent or optical brightener properties are also disclosed.

  该发明涉及一种化妆品或药用组合物，包括在生理上可接受的介质中，至少一种含有至少一种表现出光学特性的新型单体化合物的聚合物。该发明还涉及一种化妆方法，用于化妆或处理角质材料，特别是身体或面部皮肤、嘴唇、指甲、眉毛、睫毛和/或头发，包括将该化妆品组合物应用于所述材料。还公开了表现出光学特性的新型单体化合物、含有该化合物的聚合物以及将其用于组合物中以转移光学特性，特别是荧光或光亮剂特性。
• Novel block polymers, compositions comprising them, and processes for making up and/or treating therewith
  申请人：Luukas Timo

  公开号：US20050220729A1

  公开（公告）日：2005-10-06

  The present disclosure relates to novel block polymers comprising at least one monomer with an optical effect, and to cosmetic compositions comprising them, such as nail varnish compositions, foundation compositions and anti-ageing compositions. The present disclosure also relates to a cosmetic treatment process using the composition disclosed herein.

  本公开涉及包含至少一种具有光学效应的单体的新型嵌段聚合物，以及包括它们的化妆品组合物，如指甲油组合物、粉底组合物和抗衰老组合物。本公开还涉及使用此处披露的组合物的化妆品处理方法。
• Saccharide sensing molecules having enhanced fluorescent properties
  申请人：——

  公开号：US20020010279A1

  公开（公告）日：2002-01-24

  The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

  本发明提供了一种荧光化合物的配方，具有多种特性，使它们非常适合用于传感器中，用于分析物如糖类。有利的荧光特性包括有利的激发波长、发射波长、荧光寿命和光稳定性。其他有利的特性包括增强的水溶性，以及温度和pH敏感性。该化合物包括作为底物识别组分、荧光开关组分和荧光物质的芳基或取代苯基硼酸。描述了被激发波长大于400纳米并且发射波长大于450纳米的荧光化合物，这对于通过皮肤进行光传输是有利的。荧光物质通常选自过渡金属配体络合物和噻嗪、噁嗪、噁醛或噻嗪-1以及蒽化合物。该荧光化合物可以固定在葡萄糖渗透生物相容性聚合物基质中，该基质可植入皮肤下方。
• GLUCOSE SENSING MOLECULES HAVING SELECTED FLUORESCENT PROPERTIES
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP1214596A1

  公开（公告）日：2002-06-19
• US6682938B1
  申请人：——

  公开号：US6682938B1

  公开（公告）日：2004-01-27