ethyl 2-(2-oxo-2-phenylacetyl)benzoate | 95093-23-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: ethyl 2-(2-oxo-2-phenylacetyl)benzoate
• 英文别名: 2-(1,2-Dioxo-2-phenylethyl)benzoic acid ethyl ester
• CAS: 95093-23-5
• 化学式: C₁₇H₁₄O₄
• 分子量: 282.296
• InChiKey: UICBYPJPPCKEAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-(phenylethynyl)benzoate 在 三苯基膦双(三氟甲磺酰亚胺)金 、 水 、 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以82%的产率得到ethyl 2-(2-oxo-2-phenylacetyl)benzoate
  参考文献：
  名称：

  Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives

  摘要：

  A gold(I)-catalyzed oxidative diketonization of alkynes by water in the presence of Selectfluor has been achieved. The application of the present protocol for the one-pot synthesis of quinoxaline derivatives from alkynes and o-phenylenediamines has also been successful.

  DOI：

  10.1055/s-0033-1338804

文献信息

• A Combination of Copper(0) Powder and Selectfluor Enables Generation of Cationic Copper Species for Mild 1,2-Dicarbonylation of Alkynes
  作者：Yunkui Liu、Wenxia Zhang、Jian Zhang、Zhenyuan Xu

  DOI：10.1055/s-0033-1338983

  日期：——

  A combination of copper powder and Selectfluor permits the generation of cationic copper species that efficiently catalyze 1,2-dicarbonylation of alkynes under mild conditions with water and dioxygen as inexpensive and environmentally benign sources of oxygen.
• Graebe, Chemische Berichte, 1890, vol. 23, p. 1345
  作者：Graebe

  DOI：——

  日期：——
• Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives
  作者：Yunkui Liu、Xiaoling Chen、Jian Zhang、Zhenyuan Xu

  DOI：10.1055/s-0033-1338804

  日期：——

  A gold(I)-catalyzed oxidative diketonization of alkynes by water in the presence of Selectfluor has been achieved. The application of the present protocol for the one-pot synthesis of quinoxaline derivatives from alkynes and o-phenylenediamines has also been successful.