1-<(methylamino)methyl>-6,7-dimethoxytetralin | 85221-65-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-<(methylamino)methyl>-6,7-dimethoxytetralin
• 英文别名: 1-[(methylamino)methyl]-6,7-dimethoxytetralin；1-(6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylmethanamine
• CAS: 85221-65-4
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: OYQYYRSRGRYKKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(aminomethyl)-6,7-dimethoxytetralin 在 氢氧化钾 、 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 3.5h， 生成 1-<(methylamino)methyl>-6,7-dimethoxytetralin
  参考文献：
  名称：

  1-(Aminomethyl)-6,7-dihydroxytetralin derivatives: synthesis and assessment of dopamine-like effects

  摘要：

  The title compounds were designed as flexible congeners of trans-octahydrobenz[h]isoquinoline, in which the dopamine moiety can exist in the alpha conformation. Extremely low dopamine-like effects in the title series in the cat cardioaccelerator nerve assay paralleled low activity in the trans-octahydrobenz[h]isoquinoline compounds and was consistent with a prior proposal of the presence of a bulky region on the dopamine receptor(s).

  DOI：

  10.1021/jm00360a006

文献信息

• INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE HYDROBROMIDE SALT
  申请人：Richter Gedeon Nyrt.

  公开号：EP2566850B1

  公开（公告）日：2018-04-11
• 1-(Aminomethyl)-6,7-dihydroxytetralin derivatives: synthesis and assessment of dopamine-like effects
  作者：Joseph G. Cannon、Zurilma Perez、John Paul Long、Mustafa Ilhan

  DOI：10.1021/jm00360a006

  日期：1983.6

  The title compounds were designed as flexible congeners of trans-octahydrobenz[h]isoquinoline, in which the dopamine moiety can exist in the alpha conformation. Extremely low dopamine-like effects in the title series in the cat cardioaccelerator nerve assay paralleled low activity in the trans-octahydrobenz[h]isoquinoline compounds and was consistent with a prior proposal of the presence of a bulky region on the dopamine receptor(s).