7,8-dichloro-imidazo-[1,2-a]-quinoxaline-2-carboxylic acid | 76002-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7,8-dichloro-imidazo-[1,2-a]-quinoxaline-2-carboxylic acid
• 英文别名: 7,8-Dichloroimidazo[1,2-a]quinoxaline-2-carboxylic acid
• CAS: 76002-77-2
• 化学式: C₁₁H₅Cl₂N₃O₂
• 分子量: 282.086
• InChiKey: CQOJPTWSIBQWFS-UHFFFAOYSA-N

物化性质

• 熔点：
  >350 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• 密度：
  1.78±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,5-二氯邻苯二胺 在 sodium hydroxide 、 硫酸 、 硼酸 作用下， 以 乙醇 、 水 、 溶剂黄146 为溶剂， 反应 3.67h， 生成 7,8-dichloro-imidazo-[1,2-a]-quinoxaline-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles

  摘要：

  4H-Imidazo[2,1-c][1,4]benzoxazine-2-carboxylic acid (3) was found to possess potent activity in the IgE-induced rat passive cutaneous anaphylaxis model which may be predictive of clinical antiallergic activity. Compared to disodium cromoglycate (DSCG, 1), 3 was less active following iv administration but unlike DSCG showed very significant oral activity. To explore the structural requirements for this activity, a range of tricyclic compounds was prepared and their activities were measured. Individual 2-carboxylic acids derived from imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles showed iv activities up to 10(3) times as potent as DSCG and many of them showed significant oral activity. From these, imidazo[1,2-a]quinoxaline-2-carboxylic acid 114 has been chosen for further development.

  DOI：

  10.1021/jm00401a009

文献信息

• Novel imidazoquinoxalines
  申请人：Roussel Uclaf

  公开号：US04254123A1

  公开（公告）日：1981-03-03

  Novel imidazoquinoxalines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4, alkali metal, alkaline earth metal, magnesium, aluminum and non-toxic, pharmaceutically acceptable amines, X is selected from the group consisting of hydrogen, alkoxy of 1 to 5 carbon atoms and carbamoyl and Y and Z are individually selected from the group consisting of hydrogen and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity and their preparation.

  该专利描述了一种公式为##STR1##的新型咪唑喹啉类化合物，其中R选自氢、1至5个碳原子的烷基、--NH.sub.4、碱金属、碱土金属、镁、铝和非毒性、药学上可接受的胺类；X选自氢、1至5个碳原子的烷氧基和氨基甲酰基；Y和Z各自选自氢和卤素，以及它们的非毒性、药学上可接受的酸盐，具有抗过敏活性。该专利还涉及了这些化合物的制备方法。
• AGER, IAN R.;BARNES, ALAN C.;DANSWAN, GEOFFREY W.;HAIRSINE, PETER W.;KAY,+, J. MED. CHEM., 31,(1988) N 6, 1098-1115
  作者：AGER, IAN R.、BARNES, ALAN C.、DANSWAN, GEOFFREY W.、HAIRSINE, PETER W.、KAY,+

  DOI：——

  日期：——
• US4254123A
  申请人：——

  公开号：US4254123A

  公开（公告）日：1981-03-03