2-(1-indolyl-3-iodo)-1,4-naphthoquinone | 1262224-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(1-indolyl-3-iodo)-1,4-naphthoquinone
• 英文别名: 2-(3-Iodoindol-1-yl)naphthalene-1,4-dione
• CAS: 1262224-64-5
• 化学式: C₁₈H₁₀INO₂
• 分子量: 399.187
• InChiKey: HAJLGQYWCSPOEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-碘吲哚 、 2-溴-1,4-萘醌 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以19%的产率得到2-(1-indolyl-3-iodo)-1,4-naphthoquinone
  参考文献：
  名称：

  Reaction of 3-iodoindole with 1,4-naphthoquinones

  摘要：

  Abstract magnified image The usefulness of 3‐iodoindole available for introduction of an indole unit is presented. The reaction of 3‐iodoindole with 2‐bromo(or methyl)‐1,4‐naphthoquinone in acetic acid gave 2‐bromo(or methyl)‐3‐(3‐indolyl)‐1,4‐naphthoquinone. On the other hand, the reaction of 3‐iodoindole with 2‐bromo‐1,4‐naphthoquinone in the presence of cesium carbonate in acetonitrile produced 2‐(1‐indolyl‐3‐iodo)‐1,4‐naphthoquinone. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.492

文献信息

• Reaction of 3-iodoindole with 1,4-naphthoquinones
  作者：Yasuhiro Tanoue、Takashi Teraoka、Norihisa Kai、Takeshi Nagai、Kazutoshi Ushio

  DOI：10.1002/jhet.492

  日期：2010.11

  Abstract magnified image The usefulness of 3‐iodoindole available for introduction of an indole unit is presented. The reaction of 3‐iodoindole with 2‐bromo(or methyl)‐1,4‐naphthoquinone in acetic acid gave 2‐bromo(or methyl)‐3‐(3‐indolyl)‐1,4‐naphthoquinone. On the other hand, the reaction of 3‐iodoindole with 2‐bromo‐1,4‐naphthoquinone in the presence of cesium carbonate in acetonitrile produced 2‐(1‐indolyl‐3‐iodo)‐1,4‐naphthoquinone. J. Heterocyclic Chem., (2010).