10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide | 1192620-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide
• 英文别名: 7H-[1,2]benzothiazolo[3,2-b]quinazoline 5,5-dioxide
• CAS: 1192620-40-8
• 化学式: C₁₄H₁₀N₂O₂S
• 分子量: 270.312
• InChiKey: LCDHZPCGFRRYJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氰基苯磺酰氯 、 2-氨基苄胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以85%的产率得到10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide
  参考文献：
  名称：

  Microwave-Assisted, One-Pot Synthesis of 5-Thia-4b,10-diaza-indeno[2,1-a]-indene-5,5-dioxide and 10H-11-Thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide

  摘要：

  The one-pot, microwave-assisted synthesis of 5-thia-4b,10-diaza-indeno[2,1-a]indene-5,5-dioxide (6) and 10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide (7) from 1,2-phenylenediamine and 2-aminobenzylamine, respectively, is described. Generation of a sulfonamide through reaction of the appropriate diamine with 2-cyanobenzenesulfonyl chloride is followed by a multistep intramolecular transformation and subsequent elimination of ammonia to provide the corresponding tetracycle in good yield.

  DOI：

  10.1080/00397910902788182

文献信息

• Microwave-Assisted, One-Pot Synthesis of 5-Thia-4<i>b</i>,10-diaza-indeno[2,1-<i>a</i>]-indene-5,5-dioxide and 10<i>H</i>-11-Thia-5,10<i>a</i>-diaza-benzo[<i>b</i>]fluorene-11,11-dioxide
  作者：Andrew G. Cole、Steven G. Kultgen、Ian Henderson

  DOI：10.1080/00397910902788182

  日期：2009.9.18

  The one-pot, microwave-assisted synthesis of 5-thia-4b,10-diaza-indeno[2,1-a]indene-5,5-dioxide (6) and 10H-11-thia-5,10a-diaza-benzo[b]fluorene-11,11-dioxide (7) from 1,2-phenylenediamine and 2-aminobenzylamine, respectively, is described. Generation of a sulfonamide through reaction of the appropriate diamine with 2-cyanobenzenesulfonyl chloride is followed by a multistep intramolecular transformation and subsequent elimination of ammonia to provide the corresponding tetracycle in good yield.