N,2-di-p-tolylquinazolin-4-amine | 441718-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N,2-di-p-tolylquinazolin-4-amine
• 英文别名: N,2-bis(4-methylphenyl)quinazolin-4-amine
• CAS: 441718-53-2
• 化学式: C₂₂H₁₉N₃
• 分子量: 325.413
• InChiKey: XRMNVCUMFIWJNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z)-4-methyl-N-(2-p-tolyl-2,3-dihydroquinazolin-4(1H)-ylidene)aniline 在 potassium permanganate 作用下， 以 丙酮 为溶剂， 以55%的产率得到N,2-di-p-tolylquinazolin-4-amine
  参考文献：
  名称：

  Iodine-promoted facile synthesis of new (+)-2,3-dihydro-N,2-diarylquinazolines

  摘要：

  The reactivity of 2-amino-N'-arylbenzamidines 1a-e towards p-tolualdehyde 2a and 1-naphthaldehyde 2b under the catalytic influence of commercial iodine at ambient temperature has been examined. New chiral quinazolines 3a-e and 4a-d have been identified as reaction products. These products have subsequently been oxidised to N,2-diarylquinazolin-4-amines 12, 13a-d. The structures of the products were elucidated by their NMR, mass and IR spectra in addition to elemental analyses. The structure of 3e was further confirmed by X-ray structural analysis. The mechanism of formation of 3a-e and 4a-d is discussed.

  DOI：

  10.3998/ark.5550190.0011.a09

文献信息

• N-heterocyclic carbene-Pd(II)-1-methylimidazole complex-catalyzed Suzuki-Miyaura coupling of 2-chloro-4-aminoquinazolines with arylboronic acids
  作者：Zhen Bao、Zhi-Yuan Zhou、Ye-Ting Mao、Li-Xiong Shao

  DOI：10.1016/j.tet.2020.131548

  日期：2020.10

  The Suzuki-Miyaura coupling between 2-chloro-4-aminoquinazolines and arylboronic acids catalyzed by the well-defined N-heterocyclic carbene-PdCl2-1-methylimidazole complex was performed at room temperature, giving the desired products in good to high yields. Through this methodology, a variety of 2-aryl-4-aminoquinazoline derivatives with potential pharmaceutical activities can be achieved under mild reaction conditions. (C) 2020 Elsevier Ltd. All rights reserved.
• [EN] METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR AUGMENTER LES NIVEAUX DE POLYPEPTIDES EB DE FACTEUR DE TRANSCRIPTION
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2020142748A1

  公开（公告）日：2020-07-09

  This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.
• Iodine-promoted facile synthesis of new (+)-2,3-dihydro-N,2-diarylquinazolines
  作者：Kamal M. El-Shaieb、Henning Hopf、Peter G. Jones

  DOI：10.3998/ark.5550190.0011.a09

  日期：——

  The reactivity of 2-amino-N'-arylbenzamidines 1a-e towards p-tolualdehyde 2a and 1-naphthaldehyde 2b under the catalytic influence of commercial iodine at ambient temperature has been examined. New chiral quinazolines 3a-e and 4a-d have been identified as reaction products. These products have subsequently been oxidised to N,2-diarylquinazolin-4-amines 12, 13a-d. The structures of the products were elucidated by their NMR, mass and IR spectra in addition to elemental analyses. The structure of 3e was further confirmed by X-ray structural analysis. The mechanism of formation of 3a-e and 4a-d is discussed.