1-naphthol-2-sulfonic acid potassium salt | 832-49-5

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-naphthol-2-sulfonic acid potassium salt
• 英文别名: potassium salt of 1-naphthol-2-sulfonate；potassium 1-napthol-2-sulfonate；potassium 1-hydroxynaphthalenesulphonate；potassium 1-naphthol-2-sulfonate；Potassium;2-sulfonaphthalen-1-olate；potassium;2-sulfonaphthalen-1-olate
• CAS: 832-49-5
• 化学式: C₁₀H₇O₄S*K
• 分子量: 262.327
• InChiKey: LSEJAILWYFFINQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.55
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  1-naphthol-2-sulfonic acid potassium salt 在 五氯化磷 作用下， 以 氯仿 为溶剂， 反应 1.5h， 生成 1-hydroxy-naphthalene-2-sulfonyl chloride
  参考文献：
  名称：

  WO2008/409

  摘要：

  公开号：

文献信息

• OPHTHALMIC COMPOSITIONS COMPRISING dDC
  申请人：Hughes Patrick M.

  公开号：US20100056547A1

  公开（公告）日：2010-03-04

  A composition comprising dDC and a polymer, wherein the composition is an aqueous liquid with a viscosity which increases upon contact with a surface of an eye is disclosed herein. An aqueous composition comprising a therapeutically effective concentration of dDC, wherein the concentration of dDC is less than 1% is also disclosed. An eye drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 μg is also disclosed. A method comprising administering an effective amount of dDC topically to an eye of a person suffering from viral conjunctivitis a viral infection, wherein less than 300 μL of dDC is administered to said eye is also disclosed. A kit comprising a composition and a dispenser, wherein said dispenser dispenses a drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 μg is also disclosed.

  本文披露了一种包含dDC和聚合物的组合物，其中该组合物是一种水性液体，其粘度在接触眼睛表面时会增加。还披露了一种包含治疗有效浓度的dDC的水性组合物，其中dDC的浓度小于1%。还披露了一种眼用滴剂，其中含有治疗有效量的dDC，其中dDC的量小于300微克。还披露了一种方法，包括向患有病毒性结膜炎的人的眼部局部给予有效量的dDC，其中向该眼部给予的dDC少于300微升。还披露了一种包括组合物和分配器的套件，其中该分配器分配含有治疗有效量的dDC的滴剂，其中dDC的量小于300微克。
• CXCR2 INHIBITORS
  申请人：HACHTEL Stephanie

  公开号：US20090227625A1

  公开（公告）日：2009-09-10

  The invention relates to compounds of the formula I in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.

  本发明涉及公式I的化合物，其中R1、R2、X、A、B、Z和Y1到Y4具有所述权利要求中指示的含义，和/或其药学上可接受的盐和/或前药。由于它们作为趋化因子受体抑制剂的特性，尤其是作为CXCR2抑制剂，公式I的化合物及其药学上可接受的盐和前药适用于预防和治疗趋化因子介导的疾病。
• PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A Beta2-ADRENOCEPTOR AGONIST
  申请人：Ford Rhonan

  公开号：US20110190309A1

  公开（公告）日：2011-08-04

  The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is a β 2 -adrenoceptor agonist, or use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma.

  本发明提供了一种药物产品、套装或组合物，包括第一活性成分，该成分是选择的肌动蛋白受体拮抗剂，和第二活性成分，该成分是β2-肾上腺素受体激动剂，或用于治疗呼吸系统疾病，如慢性阻塞性肺疾病和哮喘。
• Integral multilayer element for chemical analysis
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0137521A2

  公开（公告）日：1985-04-17

  An integral multilayer element for chemical analysis utilizing an oxidase enzyme reaction system, which comprises in order: (a) a porous spreading layer; (b) an oxygen-permeable, protein-impermeable light-blocking layer; (c) an oxidase-containing layer; (d) an indicator layer containing peroxidase and a hydrogen peroxide indicator showing detectable change in the presence of peroxidase and hydrogen peroxide; and (e) a water-impermeable, light-transmissive support.

  一种利用氧化酶反应系统进行化学分析的整体多层元件，依次包括 (a) 多孔铺展层； (b) 透氧、蛋白质不透光的阻光层； (c) 含氧化酶层 (d) 含过氧化物酶和过氧化氢指示剂的指示剂层，在过氧化物酶和过氧化氢的存在下显示可检测到的变化；以及 (e) 不透水、透光的支架。
• QUANTITATIVE METHOD AND QUANTITATIVE CHIP FOR OBJECTIVE SUBSTANCE
  申请人：ROHM CO., LTD.

  公开号：EP1635175A1

  公开（公告）日：2006-03-15

  The present invention provides a quantitative measurement method and quantitative measurement chip which can perform quantitative measurement of a target substance in a short period of time. The invention provides a quantitative measurement method in which a three dimensional mesh structure material is formed, and quantitative measurements are taken of the target substance using a structure which contains a reagent that reacts with the target substance in the mesh. This method includes a contacting step in which a test specimen which includes the target substance is brought into contact with the structure; a detecting step which, in a process in which a substance whose quantity will increase or decrease by means of the reaction between the target substance and the reagent, detects the substance whose quantity is increasing or decreasing within the structure at a contact interface between the test specimen and the reagent; and a quantitative measurement step which performs quantitative measurement of the target substance based on the results of the detecting step. The mesh structure will allow at least the target substance to pass therethrough.

  本发明提供了一种可在短时间内对目标物质进行定量测量的定量测量方法和定量测量芯片。本发明提供了一种定量测量方法，在该方法中，形成了一种三维网状结构材料，并使用一种含有试剂的结构对目标物质进行定量测量，该试剂会与网状结构中的目标物质发生反应。该方法包括一个接触步骤，在该步骤中，包含目标物质的测试样本与该结构接触；一个检测步骤，在目标物质与试剂反应导致物质数量增加或减少的过程中，在测试样本与试剂的接触界面检测结构内数量增加或减少的物质；以及一个定量测量步骤，根据检测步骤的结果对目标物质进行定量测量。网状结构至少允许目标物质通过。

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