methyl 2-(naphthalen-2-yl)-2,3-diphenylpropanoate | 1334531-89-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: methyl 2-(naphthalen-2-yl)-2,3-diphenylpropanoate
• 英文别名: Methyl 2-naphthalen-2-yl-2,3-diphenylpropanoate；methyl 2-naphthalen-2-yl-2,3-diphenylpropanoate
• CAS: 1334531-89-3
• 化学式: C₂₆H₂₂O₂
• 分子量: 366.459
• InChiKey: BVABGTJZXCDYMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  BETA-萘乙酸甲酯 在 [Rh(OH)(cod)]2 、 4-乙酰氨基苯磺酰叠氮 、 potassium tert-butylate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲基叔丁基醚 、 乙腈 为溶剂， 反应 4.0h， 生成 methyl 2-(naphthalen-2-yl)-2,3-diphenylpropanoate
  参考文献：
  名称：

  Rhodium-Catalyzed Cross-Coupling Reaction of Arylboronates and Diazoesters and Tandem Alkylation Reaction for the Synthesis of Quaternary α,α-Heterodiaryl Carboxylic Esters

  摘要：

  A rhodium-catalyzed one-pot three-component coupling reaction was developed for the synthesis of quaternary alpha,alpha-heterodiaryl carboxylic esters. This reaction involves cross-coupling of the arylrhodium(I) complexes with alpha-aryldiazoacetates to form oxa-pi-allylrhodium complexes. With KOfBu and alkyl halides, tandem alkylation of the allyl complex occurs to form a quaternary stereocenter at the carbenic carbon.

  DOI：

  10.1021/ol2022577

文献信息

• Visible-Light-Driven Reductive Carboarylation of Styrenes with CO₂ and Aryl Halides
  作者：Hao Wang、Yuzhen Gao、Chunlin Zhou、Gang Li

  DOI：10.1021/jacs.0c03144

  日期：2020.5.6

  The first example of visible-light-driven reductive carboarylation of styrenes with CO2 and aryl halides in a regioselective manner has been achieved. A broad range of aryl iodides and bromides were compatible with this reaction. Moreover, pyridyl halides, alkyl halides and even aryl chlorides were also viable with this method. These findings may stimulate the exploration of novel visible-light-driven

  已经实现了以区​​域选择性方式将苯乙烯与 CO2 和芳基卤化物进行可见光驱动的还原碳芳基化的第一个例子。广泛的芳基碘化物和溴化物与该反应相容。此外，吡啶基卤化物、烷基卤化物甚至芳基氯化物也适用于该方法。这些发现可能会激发对新型可见光驱动的 Meerwein 芳基化加成反应的探索，该反应以用户友好的芳基卤作为自由基来源和 CO2 的光催化利用。
• Rhodium-Catalyzed Cross-Coupling Reaction of Arylboronates and Diazoesters and Tandem Alkylation Reaction for the Synthesis of Quaternary α,α-Heterodiaryl Carboxylic Esters
  作者：Yuk-Tai Tsoi、Zhongyuan Zhou、Wing-Yiu Yu

  DOI：10.1021/ol2022577

  日期：2011.10.7

  A rhodium-catalyzed one-pot three-component coupling reaction was developed for the synthesis of quaternary alpha,alpha-heterodiaryl carboxylic esters. This reaction involves cross-coupling of the arylrhodium(I) complexes with alpha-aryldiazoacetates to form oxa-pi-allylrhodium complexes. With KOfBu and alkyl halides, tandem alkylation of the allyl complex occurs to form a quaternary stereocenter at the carbenic carbon.