2,2-dimethyl-3-(1'-naphthyl)propanoic acid | 29206-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,2-dimethyl-3-(1'-naphthyl)propanoic acid
• 英文别名: 2,2-Dimethyl-3-<1>naphthyl-propionsaeure；2,2-dimethyl-3-[1]naphthyl-propionic acid；2,2-Dimethyl-3-[1]naphthyl-propionsaeure；2,2-Dimethyl-3-(naphthalen-1-yl)propanoic acid；2,2-dimethyl-3-naphthalen-1-ylpropanoic acid
• CAS: 29206-08-4
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: OGXVFCMBJLXMMR-UHFFFAOYSA-N

物化性质

• 熔点：
  98-99 °C
• 沸点：
  225-230 °C(Press: 2 Torr)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-3-(1'-naphthyl)propanoic acid 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 生成 2,2-Dimethyl-3-naphthalen-1-ylpropanoyl chloride
  参考文献：
  名称：

  Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C–H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones

  摘要：

  Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type -allcenylation of unreactive beta-C(sp(3))-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce gamma/delta-unsaturated carboxylic amide derivatives. The resulting alkenylated products can further be transformed into polysubstituted gamma-butyrolactones with pyridinium chlorochromate (PCC).

  DOI：

  10.1021/acs.orglett.5b01128
• 作为产物：
  描述：

  1-naphthylmethyl 2-methylpropanoate 在 盐酸 、 三甲基氯硅烷 、 lithium diisopropyl amide 作用下， 生成 2,2-dimethyl-3-(1'-naphthyl)propanoic acid
  参考文献：
  名称：

  Competitive [1,3]- and [3,3]-sigmatropic rearrangements

  摘要：

  DOI：

  10.1021/jo01293a024

文献信息

• Red-Light-Promoted Radical Cascade Reaction to Access Tetralins and Dialins Enabled by Zinc(II)porphyrin, A Light-Flexible Catalyst
  作者：Yusuke Okanishi、Otoki Takemoto、Sanpou Kawahara、Satoshi Hayashi、Toshikatsu Takanami、Takehiko Yoshimitsu

  DOI：10.1021/acs.orglett.4c01112

  日期：——

  15-Bis(pentafluorophenyl)-10,20-diphenylporphinato]zinc(II) (1), a metalloporphyrin derivative that was recently reported as an efficient photocatalyst driven by blue LEDs by our group, was found to catalyze a red-light-promoted (630 nm LEDs) radical cascade reaction of N-3-arylpropionyloxyphthalimides with radicophiles including electron-deficient alkenes and alkynes, providing access to a range of functionalized

  [5,15-双(五氟苯基)-10,20-二苯基卟啉]锌(II) ( 1 )是一种金属卟啉衍生物，最近被我们小组报道为一种由蓝光LED驱动的高效光催化剂，被发现可以催化红光N -3-芳基丙酰氧基邻苯二甲酰亚胺与包括缺电子烯烃和炔烃在内的亲自由基化合物进行光促进（630 nm LED）自由基级联反应，从而获得一系列功能化的四氢化萘和二氢化萘衍生物。 1催化的自由基级联反应通过DMSO中的氧化猝灭循环发生，不需要牺牲电子供体，揭示了能够促进卟啉催化的独特溶剂效应。
• Buu-Hoi; Cagniant, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1943, vol. 216, p. 346
  作者：Buu-Hoi、Cagniant

  DOI：——

  日期：——
• METHOD OF FORMING A MULTILAYER STRUCTURE
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20180282165A1

  公开（公告）日：2018-10-04

  Compositions comprising a liquid carrier and certain MX/graphitic carbon precursors are useful in forming multilayer structures having an MX layer and a graphitic carbon layer disposed on a substrate, wherein the MX layer is interposed between the substrate and the graphitic carbon layer in the multilayer structure.
• Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C–H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones
  作者：Mingliang Li、Yudong Yang、Danni Zhou、Danyang Wan、Jingsong You

  DOI：10.1021/acs.orglett.5b01128

  日期：2015.5.15

  Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type -allcenylation of unreactive beta-C(sp(3))-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce gamma/delta-unsaturated carboxylic amide derivatives. The resulting alkenylated products can further be transformed into polysubstituted gamma-butyrolactones with pyridinium chlorochromate (PCC).
• Competitive [1,3]- and [3,3]-sigmatropic rearrangements
  作者：Richard T. Arnold、Srdanka T. Kulenovic

  DOI：10.1021/jo01293a024

  日期：1980.2