tert-butyl-dimethyl-[[(2S)-piperazin-2-yl]methoxy]silane | 253781-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl-dimethyl-[[(2S)-piperazin-2-yl]methoxy]silane
• CAS: 253781-64-5
• 化学式: C₁₁H₂₆N₂OSi
• 分子量: 230.426
• InChiKey: FVVHRAQLIIBTOK-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl-dimethyl-[[(2S)-piperazin-2-yl]methoxy]silane 在 TEA 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 生成 4-tosyl (S)-2-piperazinemethanol
  参考文献：
  名称：

  Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions

  摘要：

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01031-x
• 作为产物：
  描述：

  (S)-(4-苄基哌嗪-2-基)甲醇 在 palladium on activated charcoal 氢气 作用下， 生成 tert-butyl-dimethyl-[[(2S)-piperazin-2-yl]methoxy]silane
  参考文献：
  名称：

  Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions

  摘要：

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01031-x

文献信息

• Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions
  作者：Tsutomu Inoue、Daisuke Sato、Kenichi Komura、Shinichi Itsuno

  DOI：10.1016/s0040-4039(99)01031-x

  日期：1999.7

  Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand. (C) 1999 Elsevier Science Ltd. All rights reserved.