2-[(2S,4S,5R)-4-(methoxymethoxy)-5-(trityloxymethyl)oxolan-2-yl]ethyl 4-methylbenzenesulfonate | 428453-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-[(2S,4S,5R)-4-(methoxymethoxy)-5-(trityloxymethyl)oxolan-2-yl]ethyl 4-methylbenzenesulfonate
• CAS: 428453-96-7
• 化学式: C₃₅H₃₈O₇S
• 分子量: 602.749
• InChiKey: KRLHLAMZBFMQPV-FZCBKRAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  88.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[(2S,4S,5R)-4-(methoxymethoxy)-5-(trityloxymethyl)oxolan-2-yl]ethyl 4-methylbenzenesulfonate 在 四(三苯基膦)钯 、 potassium tert-butylate 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 生成 6-ethenyl-9-[2-[(2S,4S,5R)-4-(methoxymethoxy)-5-(trityloxymethyl)oxolan-2-yl]ethyl]purin-2-amine
  参考文献：
  名称：

  Selective cross-linking to the adenine of the TA interrupting site within the triple helix

  摘要：

  The triplex-forming oligonucleotide incorporating the new nucleoside derivative (2) that connects the 2-amino-6-vinylpurine moiety to the 2-deoxyribose unit with an ethyl spacer has exhibited highly selective cross-linking reaction to the adenine of the TA interrupting site within the triple helix. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00783-1
• 作为产物：
  描述：

  2-deoxy-D-ribose 在 吡啶 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 potassium tert-butylate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 2-[(2S,4S,5R)-4-(methoxymethoxy)-5-(trityloxymethyl)oxolan-2-yl]ethyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  Selective cross-linking to the adenine of the TA interrupting site within the triple helix

  摘要：

  The triplex-forming oligonucleotide incorporating the new nucleoside derivative (2) that connects the 2-amino-6-vinylpurine moiety to the 2-deoxyribose unit with an ethyl spacer has exhibited highly selective cross-linking reaction to the adenine of the TA interrupting site within the triple helix. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00783-1

文献信息

• Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation
  作者：Keiichi Hattori、Tomoya Hirohama、Shuhei Imoto、Shuhei Kusano、Fumi Nagatsugi

  DOI：10.1039/b915381k

  日期：——

  Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

  形成寡脱氧核苷酸（ODN）的链间交联（ICL）有望确保抑制基因表达。在这篇通讯中，我们报告了一种使用 4-氨基-2-乙烯基-6-氧代嘧啶衍生物对胸腺嘧啶进行高效和选择性 ICL 反应的方法。
• Selective cross-linking to the adenine of the TA interrupting site within the triple helix
  作者：Fumi Nagatsugi、Yoshihisa Matsuyama、Minoru Maeda、Shigeki Sasaki

  DOI：10.1016/s0960-894x(01)00783-1

  日期：2002.2

  The triplex-forming oligonucleotide incorporating the new nucleoside derivative (2) that connects the 2-amino-6-vinylpurine moiety to the 2-deoxyribose unit with an ethyl spacer has exhibited highly selective cross-linking reaction to the adenine of the TA interrupting site within the triple helix. (C) 2002 Elsevier Science Ltd. All rights reserved.