[1,6]Naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide | 197507-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [1,6]Naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide
• 英文别名: N-[(2-propan-2-yloxyphenyl)methyl]-1,6-naphthyridine-2-carboxamide
• CAS: 197507-11-2
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: UAKMQXXMNQVUIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [1,6]Naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide 在 劳森试剂 作用下， 生成 [1,6]Naphthyridine-2-thiocarboxylic acid-2-isopropoxybenzylamide
  参考文献：
  名称：

  Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines

  摘要：

  1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urea derivatives showed very good activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00607-7
• 作为产物：
  描述：

  4-氨基-3-吡啶甲醛 在 sodium hydroxide 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 [1,6]Naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide
  参考文献：
  名称：

  Discovery of 1,6-Naphthyridines as a Novel Class of Potent and Selective Human Cytomegalovirus Inhibitors

  摘要：

  DOI：

  10.1021/jm9902483

文献信息

• Discovery of 1,6-Naphthyridines as a Novel Class of Potent and Selective Human Cytomegalovirus Inhibitors
  作者：Laval Chan、Haolun Jin、Tomislav Stefanac、Jean-François Lavallée、Guy Falardeau、Wei Wang、Jean Bédard、Suzanne May、Leonard Yuen

  DOI：10.1021/jm9902483

  日期：1999.8.1
• Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines
  作者：Laval Chan、Tomislav Stefanac、Jean-François Lavallée、Haolun Jin、Jean Bédard、Suzanne May、Guy Falardeau

  DOI：10.1016/s0960-894x(00)00607-7

  日期：2001.1

  1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urea derivatives showed very good activity. (C) 2001 Elsevier Science Ltd. All rights reserved.