6-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid amide | 70705-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid amide
• 英文别名: 6-Methylimidazo[1,2-a]pyridine-2-carboxamide
• CAS: 70705-31-6
• 化学式: C₉H₉N₃O
• 分子量: 175.19
• InChiKey: XQPMMOXVHSOPMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
  申请人：deCODE genetics ehf

  公开号：US20140301999A1

  公开（公告）日：2014-10-09

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is

  本发明涉及一类含有至少一个进一步环的联苯化合物。这些化合物是PDE4抑制剂，可用于治疗和预防中风、心肌梗死和心血管炎症性疾病和疾病。这些化合物的一般式为I：其中一种特定的实施形式为
• [EN] BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION<br/>[FR] INHIBITEURS DE PDE4 BIARYLE POUR TRAITER UNE INFLAMMATION
  申请人：DECODE GENETICS EHF

  公开号：WO2009067600A2

  公开（公告）日：2009-05-28

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: (formula should be inserted here). A particular embodiment is (a second formula should be inserted here)