N-isopentyl-ethylenediamine | 61798-06-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-isopentyl-ethylenediamine
• 英文别名: N-Isopentyl-aethylendiamin；N~1~-(3-Methylbutyl)ethane-1,2-diamine；N'-(3-methylbutyl)ethane-1,2-diamine
• CAS: 61798-06-9
• 化学式: C₇H₁₈N₂
• 分子量: 130.233
• InChiKey: DJOJMRGVQZGIJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  92-92.5 °C(Press: 30 Torr)
• 密度：
  0.829±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-isopentyl-ethylenediamine 在 sodium methylate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 5.0h， 生成 7-benzyl-3-isopentyl-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
  参考文献：
  名称：

  Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c02071
• 作为产物：
  描述：

  N-Neopentylaminoacetonitrile 在 sodium 、 甲苯 、 正丁醇 作用下， 生成 N-isopentyl-ethylenediamine
  参考文献：
  名称：

  Synthesis of Certain N,N-Dialkylethylenediamines¹

  摘要：

  DOI：

  10.1021/ja01220a013

文献信息

• [EN] LIPIDATED CATIONIC PEPTIDE-PEG COMPOSITIONS FOR NUCLEIC ACID DELIVERY<br/>[FR] COMPOSITIONS DE PEPTIDE-PEG CATIONIQUE LIPIDÉ DESTINÉES À L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：NUTCRACKER THERAPEUTICS INC

  公开号：WO2021030218A1

  公开（公告）日：2021-02-18

  The present disclosure relates to complexes and compositions of cationic compounds combined with low mass percentages of PEGylated compounds, such as PEGylated lipids, for the delivery of nucleic acids and other polyanionic cargoes to cells, methods for preparing complexes and compositions comprising one or more cationic compounds and a low mass percentage of PEGylated compounds with polyanionic compounds, and methods for delivering the polyanionic compounds to cells.

  本公开涉及与PEG化化合物（如PEG化脂质）结合的阳离子化合物复合物和组合物，用于将核酸和其他多阴离子载体传递给细胞，制备包含一种或多种阳离子化合物和低质量百分比PEG化化合物与多阴离子化合物的复合物和组合物的方法，以及将多阴离子化合物传递给细胞的方法。
• [EN] COMPOSITIONS AND METHODS FOR AMELIORATING PAIN<br/>[FR] COMPOSITIONS ET MÉTHODES POUR SOULAGER LA DOULEUR
  申请人：THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV AND AGRICULTURAL AND MECHANICAL COLLEGE

  公开号：WO2019040122A1

  公开（公告）日：2019-02-28

  This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.

  这项发明涉及用于治疗或缓解疼痛的组合物、方法和工具包。
• METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS USING AMINE CATALYSTS
  申请人：The Regents of the University of California

  公开号：US20170327448A1

  公开（公告）日：2017-11-16

  Provided herein are methods for producing α,β-unsaturated ketones from the condensation of methyl ketones in the presence of an amine catalyst. Such amine catalysts may be supported, for example, on a silica-alumina support. Such amine catalysts may be used in the presence of an additional acid. The α,β-unsaturated ketones may be produced by dimerization and/or timerization of the methyl ketones. Such α,β-unsaturated ketones may be suitable for use in producing fuels, gasoline additives, and/or lubricants, or precursors thereof. The methyl ketones may be obtained from renewable sources, such as by the fermentation of biomass.

  本文提供了一种制备α，β-不饱和酮的方法，该方法是通过在胺催化剂存在下对甲基酮进行缩合反应实现的。这样的胺催化剂可以被负载在二氧化硅-氧化铝载体上。这样的胺催化剂可以在存在额外酸的情况下使用。α，β-不饱和酮可以通过甲基酮的二聚化和/或三聚化产生。这样的α，β-不饱和酮可适用于生产燃料、汽油添加剂和/或润滑剂，或其前体。甲基酮可以从可再生来源获得，例如通过生物质发酵。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2025671A1

  公开（公告）日：2009-02-18

  Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R1, R2, R3, L1, L2, L3, X and Y are defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  提供了对预防、治疗或改善血栓生成素受体活化有效的疾病的化合物。 由式（I）代表的化合物（其中 R1、R2、R3、L1、L2、L3、X 和 Y 在描述中定义）、该化合物的同系物、原药或药学上可接受的盐或其溶液。
• MODIFIED BLOCK COPOLYMER, METHOD FOR PRODUCING MODIFIED BLOCK COPOLYMER, AND RESIN COMPOSITION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3623398A1

  公开（公告）日：2020-03-18

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x = 0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x = 0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x = 0 to 2) (C) satisfies the following condition: Condition: when the compound forming the atomic group having NHx (x = 0 to 2) (C) is reacted with a maleic anhydride-modified group in a maleic anhydride-modified block copolymer, a MFR value at 230°C under a load of 2.16 kg of the modified block copolymer after the reaction is 0.1 times or more a MFR value at 230°C under a load of 2.16 kg of the maleic anhydride-modified block copolymer before the reaction.

  根据本发明，改性嵌段共聚物是一种改性嵌段共聚物，包括以乙烯基芳香族化合物为主要成分的聚合物嵌段（A）、以共轭二烯化合物为主要成分的聚合物嵌段（B）和具有 NHx（x = 0 至 2）的原子团（C）。在改性嵌段聚合物中，由共轭二烯化合物作为主要成分（B）的聚合物嵌段是氢化产物，具有 NHx（x = 0 至 2）（C）的原子团包含在侧链中，形成具有 NHx（x = 0 至 2）（C）的原子团的化合物满足以下条件： 条件：当形成具有 NHx（x = 0 至 2）(C)的原子团的化合物与马来酸酐改性嵌段共聚物中的马来酸酐改性基团反应时，反应后在 230℃、负载 2.16 千克改性嵌段共聚物时的 MFR 值是反应前在 230℃、负载 2.16 千克马来酸酐改性嵌段共聚物时的 MFR 值的 0.1 倍或以上。