7-(Bromomethyl)benzo[g]quinoxaline-5,10-dione | 681831-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-(Bromomethyl)benzo[g]quinoxaline-5,10-dione
• CAS: 681831-64-1
• 化学式: C₁₃H₇BrN₂O₂
• 分子量: 303.115
• InChiKey: RTLASKFPZAGNSF-UHFFFAOYSA-N

物化性质

• 沸点：
  512.8±50.0 °C(Predicted)
• 密度：
  1.732±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吗啉 、 7-(Bromomethyl)benzo[g]quinoxaline-5,10-dione 以 N,N-二甲基甲酰胺 为溶剂， 以50%的产率得到7-(Morpholin-4-ylmethyl)benzo[g]quinoxaline-5,10-dione
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones

  摘要：

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.046
• 作为产物：
  描述：

  喹喔啉-5,8-二酮 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 、 air 、 过氧化苯甲酰 作用下， 以 乙醇 、 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 48.0h， 生成 7-(Bromomethyl)benzo[g]quinoxaline-5,10-dione
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones

  摘要：

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.046

文献信息

• Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones
  作者：Heesoon Lee、Sungmoon Cho、Kwon Namgoong、Jae-Kyung Jung、Jungsook Cho、Sung-Il Yang

  DOI：10.1016/j.bmcl.2003.12.046

  日期：2004.3

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.