7-methylbenzo[g]quinoxaline-5,10-dione | 694494-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-methylbenzo[g]quinoxaline-5,10-dione
• CAS: 694494-99-0
• 化学式: C₁₃H₈N₂O₂
• 分子量: 224.219
• InChiKey: IYXHLGVINQYFBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-methylbenzo[g]quinoxaline-5,10-dione 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 7-[(Dimethylamino)methyl]benzo[g]quinoxaline-5,10-dione
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones

  摘要：

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.046
• 作为产物：
  描述：

  喹喔啉-5,8-二酮 在 氢氧化钾 、 air 作用下， 以 乙醇 、 甲苯 为溶剂， 生成 7-methylbenzo[g]quinoxaline-5,10-dione
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones

  摘要：

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.046

文献信息

• Synthesis of 2,3,8-Trisubstituted 7H-Isoindolo[5,6-g]quinoxaline-5,7,9,11(8H)-tetraones
  作者：Heesoon Lee、Sungmoon Cho、Byeonggil Choi、Kwon Namgoong、Jae-Kyung Jung

  DOI：10.3987/com-03-9984

  日期：——

  Oxidation of 3-methyl- or 7,8-dimethylbenzo[g]quinoxalinedione produced the unusual product, dihydroxybenezo[g]quinoxaline-5,10-dionecarboxylic acid or dicarboxylic acid. This process was used for the synthesis of a series of 2,3,8-trisubstituted isoindolo[5,6-g]quinoxalinetetraone derivatives.
• Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[ g ]quinoxaline-5,10-diones
  作者：Heesoon Lee、Sungmoon Cho、Kwon Namgoong、Jae-Kyung Jung、Jungsook Cho、Sung-Il Yang

  DOI：10.1016/j.bmcl.2003.12.046

  日期：2004.3

  A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line. (C) 2003 Elsevier Ltd. All rights reserved.