1-[1-(2-Methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-3-phenylpropan-1-one | 335120-82-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-[1-(2-Methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-3-phenylpropan-1-one
• CAS: 335120-82-6
• 化学式: C₂₄H₂₈N₂O
• 分子量: 360.499
• InChiKey: ZLNMKQBBPWXNSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊醛 以 二氯甲烷 为溶剂， 反应 19.25h， 生成 1-[1-(2-Methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-3-phenylpropan-1-one
  参考文献：
  名称：

  METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS

  摘要：

  本申请公开了一种用于识别治疗或预防癌症或转移性癌症的药剂的方法，包括以下步骤：将干细胞与潜在药剂接触，并识别诱导分化的药剂，或抑制干细胞多能性或干细胞生长的药剂，其中这种药剂被确定为抗癌药剂。

  公开号：

  US20180263964A1

文献信息

• Substituted tetrahydro-β-carbolines as potential agents for the treatment of human papillomavirus infection
  作者：John F. Miller、Elizabeth M. Turner、Ronald G. Sherrill、Kristjan Gudmundsson、Andrew Spaltenstein、Phiroze Sethna、Kevin W. Brown、Robert Harvey、Karen R. Romines、Pamela Golden

  DOI：10.1016/j.bmcl.2009.10.123

  日期：2010.1

  The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range. (c) 2009 Elsevier Ltd. All rights reserved.
• AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER
  申请人：Minerva Biotechnologies Corporation

  公开号：US20210087143A1

  公开（公告）日：2021-03-25

  The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.
• AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS
  申请人：MINERVA BIOTECHNOLOGIES CORPORATION

  公开号：US20210299109A1

  公开（公告）日：2021-09-30

  The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.
• [EN] METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS<br/>[FR] PROCÉDÉ DE SÉLECTION D'AGENTS POUR DIFFÉRENCIER DES CELLULES SOUCHES
  申请人：MINERVA BIOTECHNOLOGIES CORP

  公开号：WO2017053886A2

  公开（公告）日：2017-03-30

  The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti- cancer agent.
• METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS
  申请人：MINERVA BIOTECHNOLOGIES CORPORATION

  公开号：US20180263964A1

  公开（公告）日：2018-09-20

  The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

  本申请公开了一种用于识别治疗或预防癌症或转移性癌症的药剂的方法，包括以下步骤：将干细胞与潜在药剂接触，并识别诱导分化的药剂，或抑制干细胞多能性或干细胞生长的药剂，其中这种药剂被确定为抗癌药剂。