Pentyl-sulfamyl-chlorid | 88512-82-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Pentyl-sulfamyl-chlorid
• 英文别名: N-pentylsulfamoyl chloride
• CAS: 88512-82-7
• 化学式: C₅H₁₂ClNO₂S
• 分子量: 185.675
• InChiKey: ZFXMPFUKRDENRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-戊基胺盐酸盐 在 磺酰氯 作用下， 生成 Pentyl-sulfamyl-chlorid
  参考文献：
  名称：

  Hansen,N.C., Acta Chemica Scandinavica (1947), 1963, vol. 17, p. 2141 - 2142

  摘要：

  DOI：

文献信息

• [EN] 3-DIARYLMETHYLENES AND USES THEREOF<br/>[FR] 3-DIARYLMÉTHYLÈNES ET LEURS UTILISATIONS
  申请人：ATUX ISKAY LLC

  公开号：WO2021188949A1

  公开（公告）日：2021-09-23

  3-Diarylmethylenes are disclosed. The compounds activate PP2A, suppress oncogenic kinase signaling, and negatively regulate MYC and MYCN in cancer. The compounds also induce FOXO transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

  3-二芳基亚甲基烯已被披露。这些化合物激活PP2A，抑制致癌激酶信号传导，并在癌症中负调节MYC和MYCN。这些化合物还通过调节PP2A诱导FOXO转录因子转位到细胞核，从而表现出抗增殖效应。它们在治疗各种疾病中很有用，包括作为单药治疗癌症，或与其他药物联合使用以恢复对化疗的敏感性，尤其是在出现耐药性的情况下。
• [EN] N-SUBSTITUTED-3-TRICYCLYL PIPERIDINE DERIVATIVES AS ANTICANCER AND NEUROPROTECTIVE AGENTS<br/>[FR] DÉRIVÉS DE 3-TRICYCLYL-PIPÉRIDINES N-SUBSTITUÉES UTILISÉS EN TANT QU'AGENTS ANTICANCÉREUX ET NEUROPROTECTEURS
  申请人：ICAHN SCHOOL MED MOUNT SINAI

  公开号：WO2021150697A1

  公开（公告）日：2021-07-29

  A genus of N-substituted-3-tricyclyl piperidine derivatives is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

  揭示了一种N-取代-3-三环戊二酰基哌啶衍生物的属。这些化合物属于以下属：这些化合物通过调节PP2A诱导FOXO1转录因子转位到细胞核，从而表现出抗增殖效应。它们在治疗各种疾病方面很有用，包括作为单药治疗癌症，或与其他药物联合使用以恢复对化疗的敏感性，尤其是在出现耐药性时。
• HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING THEM, USE AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：HECKEL Armin

  公开号：US20150011535A1

  公开（公告）日：2015-01-08

  The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及通式（I）的化合物，以及其互变异构体和盐，特别是其与无机或有机酸和碱形成的药用可接受盐，具有有价值的药理学特性，特别是对上皮钠通道具有抑制作用，并且用于治疗疾病，特别是肺部和气道疾病。
• [EN] NEW BRAF INHIBITORS AS PARADOX BREAKERS<br/>[FR] NOUVEAUX INHIBITEURS DE BRAF EN TANT QUE "PARADOX BREAKERS"
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021116050A1

  公开（公告）日：2021-06-17

  The invention provides a novel compound having the general formula (I) (I) wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

  该发明提供了一种具有通式(I)的新化合物(I)，其中R1-R3和X如描述和索赔中所定义。通式(I)的化合物可用作药物。
• [EN] AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS<br/>[FR] COMPOSÉS DE TYPE AMILORIDE EN TANT QU'INHIBITEURS DE CANAUX SODIUM ÉPITHÉLIAUX POUR LE TRAITEMENT DE MALADIES DES POUMONS ET DES VOIES RESPIRATOIRES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2015003958A1

  公开（公告）日：2015-01-15

  P01-2935/FF 88/88 -88- ABSTRACT The present invention relates to compounds of general formula (I) R N NNH 2 N O N H NH 2 NH 2 X A' A (I) and the tautomersand the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatmentof diseases, particularly diseases of the lungs and airways.

  本发明涉及一般式（I）R N NNH 2 N O N H NH 2 NH 2 X A' A（I）的化合物及其互变异构体和盐，特别是其与无机或有机酸和碱形成的药用可接受盐，具有有价值的药理特性，尤其是对上皮钠通道具有抑制作用，用于治疗疾病，特别是肺部和呼吸道疾病。