N-(Pyrimidinyl-2')-2-benzoxazolylamine | 88002-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: N-(Pyrimidinyl-2')-2-benzoxazolylamine
• 英文别名: N-(Pyrimidin-2-yl)-1,3-benzoxazol-2-amine；N-pyrimidin-2-yl-1,3-benzoxazol-2-amine
• CAS: 88002-39-5
• 化学式: C₁₁H₈N₄O
• mdl: MFCD24390509
• 分子量: 212.211
• InChiKey: WVJNBSOACUSDDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  嘧啶-2-基氨腈 、 2-氨基苯酚 以 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 以47%的产率得到N-(Pyrimidinyl-2')-2-benzoxazolylamine
  参考文献：
  名称：

  Cyanoamino compounds in synthesis syntheses of some heterocycles

  摘要：

  DOI：

  10.1007/bf01134190

文献信息

• Chemical inducers of neurogenesis
  申请人：Schneider Jay

  公开号：US20090036451A1

  公开（公告）日：2009-02-05

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如在成年哺乳动物大脑的分离物中，或在体内进行。本文描述的化合物和方法可能在治疗神经退行性和精神疾病、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR
  申请人：Olson Eric

  公开号：US20090076103A1

  公开（公告）日：2009-03-19

  The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.

  本发明涉及筛选化合物的屏幕，这些化合物可以诱导干细胞分化。此外，已确定异噁唑和磺酰肼是可以分别诱导干细胞分化为神经元和心脏细胞的通用化合物类别。
• CHEMICAL INDUCERS OF NEUROGENESIS
  申请人：Schneider Jay

  公开号：US20130143885A1

  公开（公告）日：2013-06-06

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如从成年哺乳动物大脑中分离出来，也可以在体内进行。本文所描述的化合物和方法可以在神经退行性和精神疾病的治疗、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• VERCEK, B.;OGOREVC, B.;STANOVNIK, B.;TISLER, M., MONATSH. CHEM., 1983, 114, N 6-7, 789-798
  作者：VERCEK, B.、OGOREVC, B.、STANOVNIK, B.、TISLER, M.

  DOI：——

  日期：——
• Stem Cell Differentiating Agents and Uses Therefor
  申请人：Olson Eric N.

  公开号：US20120029200A1

  公开（公告）日：2012-02-02

  The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.