2-甲基吡啶并[3,4-d]嘧啶-4-胺 | 63845-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 中文名称: 2-甲基吡啶并[3,4-d]嘧啶-4-胺
• 英文名称: 2-methyl-4-aminopyrido<3,4-d>pyrimidine
• 英文别名: 2-methyl-pyrido[4,3-d]pyrimidin-4-ylamine；4-Amino-2-methyl-1,3,7-triazanaphthalin；2-Methylpyrido[3,4-d]pyrimidin-4-amine
• CAS: 63845-73-8
• 化学式: C₈H₈N₄
• mdl: MFCD18802736
• 分子量: 160.178
• InChiKey: IRANOSHXWGWISK-UHFFFAOYSA-N

物化性质

• 沸点：
  270.0±22.0 °C(Predicted)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基-3H,4H-吡啶并[3,4-d]嘧啶-4-酮 在 ammonium sulfate 、 乙醇 、 苯胺 、 六甲基二硅氮烷 作用下， 生成 2-甲基吡啶并[3,4-d]嘧啶-4-胺
  参考文献：
  名称：

  Nishikawa, Shiro; Kumazawa, Zenzaburo; Kashimura, Naoki, Agricultural and Biological Chemistry, 1986, vol. 50, # 2, p. 495 - 498

  摘要：

  DOI：

文献信息

• NISHIKAWA, SHIRO;KUMAZAWA, ZENZABURO;KASHIMURA, NAOKI;MAKI, SHINJI;NISHIK+, AGR. AND BIOL. CHEM., 1986, 50, N 2, 495-497
  作者：NISHIKAWA, SHIRO、KUMAZAWA, ZENZABURO、KASHIMURA, NAOKI、MAKI, SHINJI、NISHIK+

  DOI：——

  日期：——
• Pharmaceutical compositions and methods for metabolic modulation
  申请人：Mijikovic Dusan

  公开号：US20070161582A1

  公开（公告）日：2007-07-12

  Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and dyslipidemia In still further preferred aspects, compounds with cytokinin activity are used to activate AMPK and/or Akt. Consequently, various diseases associated with dysregulation of AMPK and/or Akt may be treated using the compounds of the present inventive subject matter.
• Alimentary compositions and methods for metabolic modulation
  申请人：Miljkovic Dusan

  公开号：US20070184067A1

  公开（公告）日：2007-08-09

  Contemplated food products include compounds with cytokinin activity to modulate glucose and/or lipid metabolism, and in especially preferred aspects contemplated food products include one or more naturally occurring cytokinins (e.g., kinetin, N2-acetylguanine, zeatin, dihydrozeatin) at a concentration effective to prevent or treat pre-diabetes, insulin resistance, type-2 diabetes, syndrome X, and/or dyslipidemia. Methods of marketing such products are also contemplated.
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR METABOLIC MODULATION
  申请人：Miljkovic Dusan

  公开号：US20090203638A1

  公开（公告）日：2009-08-13

  Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and dyslipidemia. In still further preferred aspects, compounds with cytokinin activity are used to activate AMPK and/or Akt. Consequently, various diseases associated with dysregulation of AMPK and/or Akt may be treated using the compounds of the present inventive subject matter.
• Alimentary Compositions and Methods For Metabolic Modulation
  申请人：Miljkovic Dusan

  公开号：US20090208620A1

  公开（公告）日：2009-08-20

  Contemplated food products include compounds with cytokinin activity to modulate glucose and/or lipid metabolism, and in especially preferred aspects contemplated food products include one or more naturally occurring cytokinins (e.g., kinetin, N2-acetylguanine, zeatin, dihydrozeatin) at a concentration effective to prevent or treat pre-diabetes, insulin resistance, type-2 diabetes, syndrome X, and/or dyslipidemia. Methods of marketing such products are also contemplated.