10-diethylamino-decan-1-ol | 97118-29-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 10-diethylamino-decan-1-ol
• 英文别名: 10-Diaethylamino-decan-1-ol；Diaethyl-(10-hydroxy-decyl)-amin；10-Diaethylamino-1-decanol；10-(Diethylamino)decan-1-ol
• CAS: 97118-29-1
• 化学式: C₁₄H₃₁NO
• 分子量: 229.406
• InChiKey: RJYNIRBKRJAXGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-diethylamino-decan-1-ol 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 diethyl-(10-chloro-decyl)-amine
  参考文献：
  名称：

  Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity

  摘要：

  The synthesis and preliminary pharmacological profile of a new series of muscarinic antagonists, derived from previously studied 2,2-diphenyl-2-ethylthio-acetic acid esters, are reported. The parent molecules were decorated with linkers of different length, carrying an amino group to catch a putative anionic function outside the recognition site of the receptor. It was hoped that the interception of this function would give molecules with higher potency and selectivity. The attempt has not been successful, but a new series of compounds with a peculiar pharmacological profile has been identified.

  DOI：

  10.1016/j.farmac.2004.08.003
• 作为产物：
  描述：

  7-diethylcarbamoyl-nonanoic acid ethyl ester 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 10-diethylamino-decan-1-ol
  参考文献：
  名称：

  Edwards; Stenlake, Journal of Pharmacy and Pharmacology, 1955, vol. 7, p. 852,859

  摘要：

  DOI：

文献信息

• PROCESS FOR PREPARING (METH)ACRYLIC ACID
  申请人：Vogel Bernd

  公开号：US20100029979A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.

  本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂的存在下将环状酯转化为（甲基）丙烯酸。制备的（甲基）丙烯酸可以特别地转化为（甲基）丙烯酸酯。
• PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE
  申请人：Vogel Bernd

  公开号：US20100010276A1

  公开（公告）日：2010-01-14

  The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.

  本发明涉及一种制备四甲基乙二酰乙酯的方法，包括将含有至少50%重量的2-羟基异丁酸和/或四甲基乙二酰乙酯的组合物加热至至少100℃的温度。
• Neuromuscular Blocking Agents
  作者：D Edwards、J J Lewis、J B Stenlake、M S Zoha

  DOI：10.1111/j.2042-7158.1958.tb10389.x

  日期：2011.4.12

  The preparation of two further NSN-tris-ethonium compounds, 9-ethyl-9-thioniaheptadecylenebis(triethylammonium) triiodide (dioctasulphonium triethiodide; DOSE) and 11-ethyl-11-thioniaheneicosylenebis(triethylammonium) triiodide (didecasulphonium triethiodide; DDSE) is described. The bis-quaternary compound 7-dioxothiatridecylenebis(triethylammonium iodide), and the NNN-tris-quaternary compounds 7:7-diethyl-7-azoniatridecylenebis (triethylammonium) triiodide (dihexazonium triethiodide; DHAE), 9:9-diethyl-9-azoniaheptadecylenebis(triethylammonium triiodide (dioctazonium triethiodide; DOAE) and 11:11-diethyl-11-azoniahenicosylenebis(triethylammonium) triiodide (didecazonium triethiodide; DDAE) have also been synthesised. All the compounds possess neuromuscular blocking activity in the gastrocnemius muscle-sciatic nerve preparation of the cat, the phrenic nerve-diaphragm preparation of the rat and kitten and as measured by the rabbit head drop and mouse paralysis methods. Dihexazonium triethiodide and the sulphone 7-dioxathiatridecylenebis(triethylammonium iodide) (dihexone) show tubocurarine-like activity; dioctasulphonium triethiodide and dioctazonium triethiodide were predominantly tubocurarine-like but had some transitional properties, whilst didecasulphonium triethiodide and didecazonium triethiodide resembled decamethonium. Dihexazonium triethiodide was about equipotent with tubocurarine on the cat. Marked species variations in potency were observed. Theoretical implications are discussed.

  摘要：本文描述了两种新的NSN-三乙醇铵化合物的制备方法，分别为9-乙基-9-硫氮庚二烯双(三乙醇铵)三碘化物（二辛磺酸三乙硫碘酸盐；DOSE）和11-乙基-11-硫氮十二烯双(三乙醇铵)三碘化物（二十二磺酸三乙硫碘酸盐；DDSE）。还合成了双季铵化合物7-二氧代硫氮十三烯双(三乙醇铵碘化物)，以及NNN-三季铵化合物7:7-二乙基-7-氮杂硫氮十三烯双(三乙醇铵)三碘化物（二己杂铵三乙硫碘酸盐；DHAE）、9:9-二乙基-9-氮杂硫氮庚二烯双(三乙醇铵)三碘化物（二辛杂铵三乙硫碘酸盐；DOAE）和11:11-二乙基-11-氮杂硫氮十二烯双(三乙醇铵)三碘化物（二十二杂铵三乙硫碘酸盐；DDAE）。所有化合物在猫的腓肠肌-坐骨神经制备、大鼠和小猫的膈神经-膈肌制备，以及通过兔头下降和小鼠麻痹方法测量时均具有神经肌肉阻滞活性。二己杂铵三乙硫碘酸盐和7-二氧代硫氮十三烯双(三乙醇铵碘化物)（二己酮）表现出肌松药物样的活性；二辛磺酸三乙硫碘酸盐和二辛杂铵三乙硫碘酸盐主要表现出肌松药物样的特性，但也具有一些过渡性质，而二十二磺酸三乙硫碘酸盐和二十二杂铵三乙硫碘酸盐类似于十甲铵。在猫中，二己杂铵三乙硫碘酸盐的效力与肉豆蔻碱大致相同。观察到显著的物种差异。讨论了理论意义。
• [EN] METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS<br/>[FR] MODE D'EMPLOI DE DERIVES DU TRIARYL-ETHYLENE POUR LE TRAITEMENT ET LA PREVENTION DE L'OSTEOPOROSE
  申请人：HOECHST MARION ROUSSEL, INC.

  公开号：WO1996016646A1

  公开（公告）日：1996-06-06

  (EN) The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention of bone tissue loss or osteoporosis.(FR) Mode d'emploi de dérivés du triaryl-éthylène pour le traitement et la prévention de la raréfaction du tissu osseux ou ostéoporose.

  该发明涉及使用三芳基乙烯衍生物治疗或预防骨组织流失或骨质疏松的方法。
• Recombinant cell producing 2-hydroxyisobutyric acid
  申请人：Reinecke Liv

  公开号：US10174349B2

  公开（公告）日：2019-01-08

  The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.

  本发明涉及一种经过基因修饰的细胞，与野生型相比，该细胞能够产生更多的 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的更多的聚羟基烷酸酯，其特征在于 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的聚羟基烷酸酯是通过乙酰乙酰辅酶 A 作为中间体和 3-羟基丁酰辅酶 A 作为前体产生的。