(E)-2-(1-(2-phenylhydrazono)ethyl)-3H-benzo[f]chromen-3-one | 107096-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (E)-2-(1-(2-phenylhydrazono)ethyl)-3H-benzo[f]chromen-3-one
• 英文别名: 2-(1-phenylhydrazono-ethyl)-benzo[f]chromen-3-one；2-(1-Phenylhydrazono-aethyl)-benzo[f]chromen-3-on；2-[(1E)-1-(2-Phenylhydrazin-1-ylidene)ethyl]-3H-benzo[F]chromen-3-one；2-[(E)-N-anilino-C-methylcarbonimidoyl]benzo[f]chromen-3-one
• CAS: 107096-91-3
• 化学式: C₂₁H₁₆N₂O₂
• 分子量: 328.37
• InChiKey: RGMSVAQUTNHMBM-HYARGMPZSA-N

物化性质

• 熔点：
  200 °C(Solv: acetic acid (64-19-7))
• 沸点：
  549.1±60.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-2-(1-(2-phenylhydrazono)ethyl)-3H-benzo[f]chromen-3-one 、 丁炔二酸二乙酯 反应 10.0h， 以76%的产率得到diethyl 3-(3-oxo-3H-benzo(f)chromene-2-yl)-1-phenyl-1H-pyrazole-4,5-dicarboxylate
  参考文献：
  名称：

  Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates

  摘要：

  2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H)-ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100 degrees C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.03.042
• 作为产物：
  描述：

  2-羟基-1-萘甲醛 在 哌啶 、 溶剂黄146 作用下， 以 甲醇 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 4.5h， 生成 (E)-2-(1-(2-phenylhydrazono)ethyl)-3H-benzo[f]chromen-3-one
  参考文献：
  名称：

  Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates

  摘要：

  2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H)-ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100 degrees C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.03.042

文献信息

• Bartsch, Chemische Berichte, 1903, vol. 36, p. 1968
  作者：Bartsch

  DOI：——

  日期：——
• Knoevenagel; Schroeter, Chemische Berichte, 1904, vol. 37, p. 4486
  作者：Knoevenagel、Schroeter

  DOI：——

  日期：——
• BEDAIR A. H.; ALY F. A.; EL-AGRODY A. M., J. SERB. CHEM. SOC., 51,(1986) N 4, 213-218
  作者：BEDAIR A. H.、 ALY F. A.、 EL-AGRODY A. M.

  DOI：——

  日期：——
• Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates
  作者：J. Ashok Kumar、G. Saidachary、G. Mallesham、B. Sridhar、Nishant Jain、Shashi Vardhan Kalivendi、V. Jayathirtha Rao、B. China Raju

  DOI：10.1016/j.ejmech.2013.03.042

  日期：2013.7

  2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H)-ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100 degrees C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed. (C) 2013 Elsevier Masson SAS. All rights reserved.