1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(trifluoromethyl)phenyl]-1-aziridinyl]- | 682808-48-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(trifluoromethyl)phenyl]-1-aziridinyl]-
• 英文别名: 2-[2-[4-(trifluoromethyl)phenyl]aziridin-1-yl]isoindole-1,3-dione
• CAS: 682808-48-6
• 化学式: C₁₇H₁₁F₃N₂O₂
• 分子量: 332.282
• InChiKey: CFRHGAFBMMVLKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  40.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对三氟甲基苯乙烯 、 氨基邻苯二甲胺 在 碘苯二乙酸 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以97%的产率得到1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(trifluoromethyl)phenyl]-1-aziridinyl]-
  参考文献：
  名称：

  Aziridination of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate

  摘要：

  Aziridination of a variety of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate under mild conditions (K2CO3, CH2Cl2) and ambient temperature were achieved in good to excellent yields (up to 99%), and conversions. The practicality and simplicity of this C-N bond formation protocol was exemplified by its application to the aziridination of cholesteryl acetate in a stereoselective manner. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.01.127

文献信息

• Aryl Iodide Mediated Aziridination of Alkenes
  作者：Jiayin Li、Philip Wai Hong Chan、Chi-Ming Che

  DOI：10.1021/ol052293c

  日期：2005.12.1

  Aryl iodide mediated aziridination of a variety of alkenes with N-aminophthalimide under mild conditions (m-CPBA, K(2)CO(3), CH(2)Cl(2), 25 degrees C) was achieved in moderate to good yields (up to 94%). By recovering the aryl iodide, a recyclable system is developed with product yield over 79% attained for the aziridination of trans-1,2-diphenylethylene.